MedKoo Cat#: 2081758 | Name: ST-115

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ST-115 is a potent and specific inhibitor of aminopeptidase P2. When ST-115 is administered intravenously at the start of reperfusion, it reduces bradykinin degradation. This increases bradykinin's concentration in the capillaries and enhances its protective effects.

Chemical Structure

ST-115
CAS#1840873-90-6

Theoretical Analysis

MedKoo Cat#: 2081758

Name: ST-115

CAS#: 1840873-90-6

Chemical Formula: C21H32FN3O5S

Exact Mass: 457.2047

Molecular Weight: 457.56

Elemental Analysis: C, 55.13; H, 7.05; F, 4.15; N, 9.18; O, 17.48; S, 7.01

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
ST115, ST 115, ST11-5
IUPAC/Chemical Name
(R)-1-(((2S,4S)-4-Fluoro-1-((S)-2-mercapto-4-methylpentanoyl)pyrrolidine-2-carbonyl)-L-prolyl)pyrrolidine-3-carboxylic acid
InChi Key
DKBWLNDADVOGHF-XAJHFOFHSA-N
InChi Code
InChI=1S/C21H32FN3O5S/c1-12(2)8-17(31)20(28)25-11-14(22)9-16(25)19(27)24-6-3-4-15(24)18(26)23-7-5-13(10-23)21(29)30/h12-17,31H,3-11H2,1-2H3,(H,29,30)/t13-,14+,15+,16+,17+/m1/s1
SMILES Code
O=C([C@H]1CN(C([C@H]2N(C([C@H]3N(C([C@@H](S)CC(C)C)=O)C[C@@H](F)C3)=O)CCC2)=O)CC1)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 457.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
This message contains search results from the National Center for Biotechnology Information (NCBI) at the U.S. National Library of Medicine (NLM). Do not reply directly to this message Sent On: Mon Aug 01 12:06:33 2022 Search: ST-115 9 selected items PubMed Results Items 1-9 of 9 (Display the 9 citations in PubMed) 1: Mikhayel M, Leclercq SO, Sarkis DK, Doublet B. Occurrence of the Colistin Resistance Gene mcr-1 and Additional Antibiotic Resistance Genes in ESBL/AmpC-Producing Escherichia coli from Poultry in Lebanon: A Nationwide Survey. Microbiol Spectr. 2021 Oct 31;9(2):e0002521. doi: 10.1128/Spectrum.00025-21. Epub 2021 Sep 8. PMID: 34494875; PMCID: PMC8557922. 2: Lenz MR, Tsai SY, Roessler AE, Wang Y, Sethupathi P, Jones WK, Kartje GL, Simmons WH. A Potent Inhibitor of Aminopeptidase P2 Reduces Reperfusion Injury in Models of Myocardial Infarction and Stroke. J Pharmacol Exp Ther. 2022 Mar;380(3):220-229. doi: 10.1124/jpet.121.000875. Epub 2022 Jan 3. PMID: 34980660. 3: Chen YZ, Li T, Yang J, Li QM, Zhang GC, Zhang J. Transcriptomic analysis of interactions between Lymantria dispar larvae and carvacrol. Pestic Biochem Physiol. 2022 Feb;181:105012. doi: 10.1016/j.pestbp.2021.105012. Epub 2021 Dec 16. PMID: 35082035. 4: Gonzalez P, Castañeda SF, Dale J, Medeiros EA, Buelna C, Nuñez A, Espinoza R, Talavera GA. Spiritual well-being and depressive symptoms among cancer survivors. Support Care Cancer. 2014 Sep;22(9):2393-400. doi: 10.1007/s00520-014-2207-2. Epub 2014 Apr 2. PMID: 24691887; PMCID: PMC4324591. 5: Jiménez-Morillo NT, González-Pérez JA, Almendros G, De la Rosa JM, Waggoner DC, Jordán A, Zavala LM, González-Vila FJ, Hatcher PG. Ultra-high resolution mass spectrometry of physical speciation patterns of organic matter in fire- affected soils. J Environ Manage. 2018 Nov 1;225:139-147. doi: 10.1016/j.jenvman.2018.07.069. Epub 2018 Aug 2. PMID: 30077885. 6: Koletsi-Kounari H, Tzavara C, Tountas Y. Health-related lifestyle behaviours, socio-demographic characteristics and use of dental health services in Greek adults. Community Dent Health. 2011 Mar;28(1):47-52. PMID: 21485234. 7: Diamanti I, Koletsi-Kounari H, Mamai-Homata E, Vougiouklakis G. Effect of fluoride and of calcium sodium phosphosilicate toothpastes on pre-softened dentin demineralization and remineralization in vitro. J Dent. 2010 Aug;38(8):671-7. doi: 10.1016/j.jdent.2010.05.010. Epub 2010 Jun 9. PMID: 20546825. 8: Roy S, Tibesar RJ, Daly K, Pambucian S, Lee HK, Gapany M, Adams GL. Role of planned neck dissection for advanced metastatic disease in tongue base or tonsil squamous cell carcinoma treated with radiotherapy. Head Neck. 2002 May;24(5):474-81. doi: 10.1002/hed.10078. PMID: 12001078. 9: Tseng HH, Tseng TC. Effects of butylated hydroxyanisole, butylated hydroxytoluene and tertiary butylhydroquinone on growth and luteoskyrin production byPenicillium islandicum. Mycopathologia. 1995;129(2):73-8. doi: 10.1007/BF01103463. PMID: 20878563.