DL77 | H3R Antagonist

MedKoo Cat#: 564924 | Name: DL77

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DL77 is a histamine H3R antagonist, attenuating autistic behaviors in a prenatal valproic acid-induced mouse model of autism.

Chemical Structure

DL77

CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564924

Name: DL77

CAS#: NONE

Chemical Formula: C19H31NO

Exact Mass: 289.2406

Molecular Weight: 289.46

Elemental Analysis: C, 78.84; H, 10.80; N, 4.84; O, 5.53

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

DL-77; DL 77; DL77

IUPAC/Chemical Name

1-(3-(4-tert-Pentylphenoxy) propyl)piperidine

InChi Key

LAKVEWGOEMZVEF-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H31NO/c1-4-19(2,3)17-9-11-18(12-10-17)21-16-8-15-20-13-6-5-7-14-20/h9-12H,4-8,13-16H2,1-3H3

SMILES Code

CCC(C1=CC=C(OCCCN2CCCCC2)C=C1)(C)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 289.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Bahi A, Sadek B, Nurulain SM, Łażewska D, Kieć-Kononowicz K. The novel non-imidazole histamine H3 receptor antagonist DL77 reduces voluntary alcohol intake and ethanol-induced conditioned place preference in mice. Physiol Behav. 2015 Nov 1;151:189-97. doi: 10.1016/j.physbeh.2015.07.012. Epub 2015 Jul 10. PubMed PMID: 26169446. 2: Sadek B, Saad A, Subramanian D, Shafiullah M, Łażewska D, Kieć-Kononowiczc K. Anticonvulsant and procognitive properties of the non-imidazole histamine H3 receptor antagonist DL77 in male adult rats. Neuropharmacology. 2016 Jul;106:46-55. doi: 10.1016/j.neuropharm.2015.10.023. Epub 2015 Oct 23. PubMed PMID: 26525191. 3: Eissa N, Khan N, Ojha SK, Łazewska D, Kieć-Kononowicz K, Sadek B. The Histamine H3 Receptor Antagonist DL77 Ameliorates MK801-Induced Memory Deficits in Rats. Front Neurosci. 2018 Feb 12;12:42. doi: 10.3389/fnins.2018.00042. eCollection 2018. PubMed PMID: 29483860; PubMed Central PMCID: PMC5816071. 4: Eissa N, Jayaprakash P, Azimullah S, Ojha SK, Al-Houqani M, Jalal FY, Łażewska D, Kieć-Kononowicz K, Sadek B. The histamine H3R antagonist DL77 attenuates autistic behaviors in a prenatal valproic acid-induced mouse model of autism. Sci Rep. 2018 Aug 30;8(1):13077. doi: 10.1038/s41598-018-31385-7. PubMed PMID: 30166610; PubMed Central PMCID: PMC6117350.