2D216 | CAS#313520-90-0 | Activator

MedKoo Cat#: 208167 | Name: 2D216

Description:

WARNING: This product is for research use only, not for human or veterinary use.

2D216 is a compound which increased murine antigen-specific antibody responses when used as a co-adjuvant with LPS. 2D216 had minimal, if any, activity on Jurkat T cells but induced cytokine production and surface expression of costimulatory molecules on cells with antigen-presenting functions.

Chemical Structure

2D216

CAS#313520-90-0

Theoretical Analysis

MedKoo Cat#: 208167

Name: 2D216

CAS#: 313520-90-0

Chemical Formula: C23H25N3O3S2

Exact Mass: 455.1337

Molecular Weight: 455.59

Elemental Analysis: , 60.64; H, 5.53; N, 9.22; O, 10.54; S, 14.07

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

2D-216, 2-D216, 2D2-16

IUPAC/Chemical Name

N-(4-(2,5-Dimethylphenyl)thiazol-2-yl)-4-(piperidin-1-ylsulfonyl)benzamide

InChi Key

BTGZFQBGMJUKJY-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H25N3O3S2/c1-16-6-7-17(2)20(14-16)21-15-30-23(24-21)25-22(27)18-8-10-19(11-9-18)31(28,29)26-12-4-3-5-13-26/h6-11,14-15H,3-5,12-13H2,1-2H3,(H,24,25,27)

SMILES Code

O=C(NC1=NC(C2=CC(C)=CC=C2C)=CS1)C3=CC=C(S(=O)(N4CCCCC4)=O)C=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 455.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Saito T, Shukla NM, Sato-Kaneko F, Sako Y, Hosoya T, Yao S, Lao FS, Messer K, Pu M, Chan M, Chu PJ, Cottam HB, Hayashi T, Carson DA, Corr M. Small Molecule Calcium Channel Activator Potentiates Adjuvant Activity. ACS Chem Biol. 2022 Jan 21;17(1):217-229. doi: 10.1021/acschembio.1c00883. Epub 2022 Jan 5. PMID: 34985883; PMCID: PMC8788586. Saito T, Sako Y, Sato-Kaneko F, Hosoya T, Yao S, Lao FS, Shpigelman J, Messer K, Pu M, Shukla NM, Chan M, Chu PJ, Cottam HB, Hayashi T, Carson DA, Corr M. Small Molecule Potentiator of Adjuvant Activity Enhancing Survival to Influenza Viral Challenge. Front Immunol. 2021 Sep 28;12:701445. doi: 10.3389/fimmu.2021.701445. PMID: 34650551; PMCID: PMC8505803.