MedKoo Cat#: 112129 | Name: Conglobatin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Conglobatin disrupts binding of heat shock protein 90 (Hsp90) to the co-chaperone Cdc37 complex and induces downregulation of client protein expression in SK-BR-3 breast cancer cells.

Chemical Structure

Conglobatin
Conglobatin
CAS#72263-05-9

Theoretical Analysis

MedKoo Cat#: 112129

Name: Conglobatin

CAS#: 72263-05-9

Chemical Formula: C28H38N2O6

Exact Mass: 498.2730

Molecular Weight: 498.62

Elemental Analysis: C, 67.45; H, 7.68; N, 5.62; O, 19.25

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Synonym
Conglobatin
IUPAC/Chemical Name
(3E,5R,7S,8S,11Z,13R,15S,16S)-3,5,7,11,13,15-hexamethyl-8,16-bis(oxazol-5-ylmethyl)-1,9-dioxacyclohexadeca-3,11-diene-2,10-dione
InChi Key
LAJRJVDLKYGLOO-ZOMHODHKSA-N
InChi Code
InChI=1S/C28H38N2O6/c1-17-7-19(3)25(11-23-13-29-15-33-23)35-28(32)22(6)10-18(2)8-20(4)26(12-24-14-30-16-34-24)36-27(31)21(5)9-17/h9-10,13-20,25-26H,7-8,11-12H2,1-6H3/b21-9-,22-10+/t17-,18-,19+,20+,25+,26+/m1/s1
SMILES Code
C[C@@H](C[C@H](/C=C1/C)C)[C@@H](OC(/C(C)=C/[C@@H](C[C@@H]([C@@H](OC1=O)CC2=CN=CO2)C)C)=O)CC3=CN=CO3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 498.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lacey HJ, Booth TJ, Vuong D, Rutledge PJ, Lacey E, Chooi YH, Piggott AM. Conglobatins B-E: cytotoxic analogues of the C2-symmetric macrodiolide conglobatin. J Antibiot (Tokyo). 2020 Nov;73(11):756-765. doi: 10.1038/s41429-020-0332-3. Epub 2020 Jun 17. PMID: 32555501. 2: Zhou Y, Murphy AC, Samborskyy M, Prediger P, Dias LC, Leadlay PF. Iterative Mechanism of Macrodiolide Formation in the Anticancer Compound Conglobatin. Chem Biol. 2015 Jun 18;22(6):745-54. doi: 10.1016/j.chembiol.2015.05.010. PMID: 26091168; PMCID: PMC4504003. 3: Westley JW, Liu CM, Evans RH, Blount JF. Conglobatin, a novel macrolide dilactone from Streptomyces conglobatus ATCC 31005. J Antibiot (Tokyo). 1979 Sep;32(9):874-7. doi: 10.7164/antibiotics.32.874. PMID: 511778. 4: Lacey H, Chen R, Vuong D, Cowled MS, Lacey E, Rutledge PJ, Piggott AM. Yeppoonic acids A - D: 1,2,4-trisubstituted arene carboxylic acid co-metabolites of conglobatin from an Australian Streptomyces sp. J Antibiot (Tokyo). 2022 Feb;75(2):108-112. doi: 10.1038/s41429-021-00493-4. Epub 2021 Dec 9. PMID: 34880415.