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MedKoo Cat#: 413272 | Name: Copovithane

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Copovithane is a synthetic polymer, that has been shown to have antitumor activity and also to reduce mortality in experimental murine peritonitis.

Chemical Structure

Copovithane
CAS#68045-74-9

Theoretical Analysis

MedKoo Cat#: 413272

Name: Copovithane

CAS#: 68045-74-9

Chemical Formula: C14H23N3O5

Exact Mass: 313.1638

Molecular Weight: 313.35

Elemental Analysis: C, 53.66; H, 7.40; N, 13.41; O, 25.53

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Copovithane; BAY-I7433; BAY-I 7433; BAY-I-7433
IUPAC/Chemical Name
2-methylenepropane-1,3-diyl bis(methylcarbamate) compound with 1-vinylpyrrolidin-2-one (1:1)
InChi Key
KLHOCOQBFKYOMR-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H14N2O4.C6H9NO/c1-6(4-13-7(11)9-2)5-14-8(12)10-3;1-2-7-5-3-4-6(7)8/h1,4-5H2,2-3H3,(H,9,11)(H,10,12);2H,1,3-5H2
SMILES Code
CNC(OCC(COC(NC)=O)=C)=O.C=CN1CCCC1=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM comments
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 313.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Rosenblum MG, Hortobagyi GN. Pharmacokinetics and tissue disposition of the biological response modifier BAY i 7433 (copovithane) in patients with cancer. Cancer Chemother Pharmacol. 1986;18(3):247-51. doi: 10.1007/BF00273396. PMID: 3802380. 2: Wingender W. High-performance liquid chromatographic method for the quantitative analysis of a synthetic copolymer with antitumor activity (copovithane) and methylamine in human blood plasma and urine. J Chromatogr. 1983 Apr 8;273(2):319-26. doi: 10.1016/s0378-4347(00)80952-4. PMID: 6863446. 3: Hershman MJ, Trachtenberg LS, Pietsch JD, Mooney TH, DeWeese RC, Cheadle WG. Evaluation of copovithane as a nonspecific immunomodulator in surgically simulated sepsis. J Invest Surg. 1989;2(4):423-9. doi: 10.3109/08941938909018267. PMID: 2488006. 4: Hortobagyi GN, Hersh EM, Papadopoulos NE, Frye D, Rios A, Reuben JM, Plager C, Rosenblum M, Quesada J. Initial clinical studies with copovithane. J Biol Response Mod. 1986 Aug;5(4):319-29. PMID: 2942646. 5: Moffat FL, Clark AG, Falk M, Teodorczyk-Injeyan JA, Makowka L, Falk JA, Falk RE. Enhanced survival in antibiotic-treated murine fecal peritonitis by administration of copovithane, a selective immunostimulative polymer. J Surg Res. 1985 May;38(5):494-500. doi: 10.1016/0022-4804(85)90067-8. PMID: 3990277. 6: Ajani JA, Hortobagyi GN, Frye D, Levin B, Boman BM, Faintuch JS. A randomized study of two schedules of copovithane in patients with advanced colorectal carcinoma. Am J Clin Oncol. 1987 Apr;10(2):139-40. doi: 10.1097/00000421-198704000-00048. PMID: 3551577. 7: Ucci G, Riccardi A, Danova M, Faravelli M, Salvini P, Girino M. Clinical trial of high doses of Bay I 7433 (Copovithane). Drugs Exp Clin Res. 1986;12(8):713-5. PMID: 3530678. 8: Moffat FL, Falk RE, Teodorczyk-Injeyan J, Clark AG, Gilas T, Falk M, Dalfen R, Rotstein LE, McDonell M, Makowka L, et al. Reversal of cyclosporine-induced mortality with a synthetic polymeric immunostimulant in a murine model of fecal peritonitis. Transplantation. 1985 Apr;39(4):369-74. doi: 10.1097/00007890-198504000-00006. PMID: 3885487. 9: Ajani JA, Faintuch JS, McClure RK, Levin B, Boman BM, Krakoff IH. Phase II study of spirogermanium in patients with advanced colorectal carcinoma. Invest New Drugs. 1986;4(4):383-5. doi: 10.1007/BF00173512. PMID: 3583645.