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MedKoo Cat#: 526324 | Name: SCH-50910 free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SCH-50910 is a GABAB receptor antagonist

Chemical Structure

SCH-50910 free base
SCH-50910 free base
CAS#790633-59-9

Theoretical Analysis

MedKoo Cat#: 526324

Name: SCH-50910 free base

CAS#: 790633-59-9

Chemical Formula: C8H15NO3

Exact Mass: 173.1052

Molecular Weight: 173.21

Elemental Analysis: C, 55.47; H, 8.73; N, 8.09; O, 27.71

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SCH-50910 free base; SCH 50910; SCH50910.
IUPAC/Chemical Name
2-Morpholineacetic acid, 5,5-dimethyl-, (2R)-
InChi Key
InChi Code
SMILES Code
O=C(O)C[C@@H]1CNC(C)(C)CO1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 173.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Brown JW, Moeller A, Schmidt M, Turner SC, Nimmrich V, Ma J, Rueter LE, van der Kam E, Zhang M. Anticonvulsant effects of structurally diverse GABA(B) positive allosteric modulators in the DBA/2J audiogenic seizure test: Comparison to baclofen and utility as a pharmacodynamic screening model. Neuropharmacology. 2016 Feb;101:358-69. doi: 10.1016/j.neuropharm.2015.10.009. PubMed PMID: 26471422. 2: Minic Z, O'Leary DS, Scislo TJ. NTS adenosine A2a receptors inhibit the cardiopulmonary chemoreflex control of regional sympathetic outputs via a GABAergic mechanism. Am J Physiol Heart Circ Physiol. 2015 Jul 1;309(1):H185-97. doi: 10.1152/ajpheart.00838.2014. PubMed PMID: 25910812; PubMed Central PMCID: PMC4491516. 3: Parker DA, Marino V, Ong J. Pharmacological actions of thymol and an analogue at GABAB autoreceptors. Clin Exp Pharmacol Physiol. 2014 Sep;41(9):623-7. doi: 10.1111/1440-1681.12278. PubMed PMID: 25115309. 4: van Nieuwenhuijzen PS, McGregor IS, Chebib M, Hunt GE. Regional Fos-expression induced by γ-hydroxybutyrate (GHB): comparison with γ-butyrolactone (GBL) and effects of co-administration of the GABAB antagonist SCH 50911 and putative GHB antagonist NCS-382. Neuroscience. 2014 Sep 26;277:700-15. doi: 10.1016/j.neuroscience.2014.07.056. PubMed PMID: 25088910. 5: Lee BH, Ku JY, Zhao RJ, Kim HY, Yang CH, Gwak YS, Chang SC, Kim NJ, Kim JS, Lee YK, Lee HJ, Lim SC. Acupuncture at HT7 suppresses morphine self-administration at high dose through GABA system. Neurosci Lett. 2014 Jul 25;576:34-9. doi: 10.1016/j.neulet.2014.05.050. PubMed PMID: 24905174. 6: Yoon SS, Seo JW, Ann SH, Kim HY, Kim HS, Cho HY, Yun J, Chung EY, Koo JS, Yang CH. Effects of saikosaponin A on cocaine self-administration in rats. Neurosci Lett. 2013 Oct 25;555:198-202. doi: 10.1016/j.neulet.2013.09.029. PubMed PMID: 24076136. 7: Parker DA, Marino V. GABA heteroreceptors modulate noradrenaline release in human dental pulp. J Dent Res. 2013 Nov;92(11):1017-21. doi: 10.1177/0022034513505771. PubMed PMID: 24056226. 8: McKay BM, Oh MM, Disterhoft JF. Learning increases intrinsic excitability of hippocampal interneurons. J Neurosci. 2013 Mar 27;33(13):5499-506. doi: 10.1523/JNEUROSCI.4068-12.2013. PubMed PMID: 23536065; PubMed Central PMCID: PMC3678545. 9: Morse BL, Vijay N, Morris ME. γ-Hydroxybutyrate (GHB)-induced respiratory depression: combined receptor-transporter inhibition therapy for treatment in GHB overdose. Mol Pharmacol. 2012 Aug;82(2):226-35. doi: 10.1124/mol.112.078154. PubMed PMID: 22561075; PubMed Central PMCID: PMC3400846. 10: Lee JH, Kim HY, Jang EY, Choi SH, Han CH, Lee BH, Yang CH. Effect of acupuncture on naloxone-precipitated withdrawal syndrome in morphine-experienced rats: the mediation of GABA receptors. Neurosci Lett. 2011 Oct 31;504(3):301-5. doi: 10.1016/j.neulet.2011.09.052. PubMed PMID: 21982805. 11: Vollrath-Smith FR, Shin R, Ikemoto S. Synergistic interaction between baclofen administration into the median raphe nucleus and inconsequential visual stimuli on investigatory behavior of rats. Psychopharmacology (Berl). 2012 Mar;220(1):15-25. doi: 10.1007/s00213-011-2450-x. PubMed PMID: 21904820; PubMed Central PMCID: PMC3245792. 12: Gannon RL, Millan MJ. Positive allosteric modulators at GABAB receptors exert intrinsic actions and enhance the influence of baclofen on light-induced phase shifts of hamster circadian activity rhythms. Pharmacol Biochem Behav. 2011 Oct;99(4):712-7. doi: 10.1016/j.pbb.2011.06.029. PubMed PMID: 21756929. 13: Zhang M, Liu Y, Wang SZ, Zhong W, Liu BH, Tao HW. Functional elimination of excitatory feedforward inputs underlies developmental refinement of visual receptive fields in zebrafish. J Neurosci. 2011 Apr 6;31(14):5460-9. doi: 10.1523/JNEUROSCI.6220-10.2011. PubMed PMID: 21471382; PubMed Central PMCID: PMC3095389. 14: Wu Y, Wang HY, Lin CC, Lu HC, Cheng SJ, Chen CC, Yang HW, Min MY. GABAB receptor-mediated tonic inhibition of noradrenergic A7 neurons in the rat. J Neurophysiol. 2011 Jun;105(6):2715-28. doi: 10.1152/jn.00459.2010. PubMed PMID: 21430282. 15: Parker DA, Marino V, Sullivan T, Ong J, Khalafy J, Badali M, Rimaz M, Prager RH. Pharmacological actions of oximino-propofol analogues at GABA(B) autoreceptors. Clin Exp Pharmacol Physiol. 2011 Apr;38(4):203-7. doi: 10.1111/j.1440-1681.2011.05484.x. PubMed PMID: 21255061. 16: Silberman Y, Ariwodola OJ, Chappell AM, Yorgason JT, Weiner JL. Lateral paracapsular GABAergic synapses in the basolateral amygdala contribute to the anxiolytic effects of beta 3 adrenoceptor activation. Neuropsychopharmacology. 2010 Aug;35(9):1886-96. doi: 10.1038/npp.2010.59. PubMed PMID: 20410872; PubMed Central PMCID: PMC3055643. 17: Zhou Y, Liu BH, Wu GK, Kim YJ, Xiao Z, Tao HW, Zhang LI. Preceding inhibition silences layer 6 neurons in auditory cortex. Neuron. 2010 Mar 11;65(5):706-17. doi: 10.1016/j.neuron.2010.02.021. PubMed PMID: 20223205; PubMed Central PMCID: PMC2904750. 18: Takesian AE, Kotak VC, Sanes DH. Presynaptic GABA(B) receptors regulate experience-dependent development of inhibitory short-term plasticity. J Neurosci. 2010 Feb 17;30(7):2716-27. doi: 10.1523/JNEUROSCI.3903-09.2010. PubMed PMID: 20164356; PubMed Central PMCID: PMC3842473. 19: Shin R, Ikemoto S. The GABAB receptor agonist baclofen administered into the median and dorsal raphe nuclei is rewarding as shown by intracranial self-administration and conditioned place preference in rats. Psychopharmacology (Berl). 2010 Mar;208(4):545-54. doi: 10.1007/s00213-009-1757-3. PubMed PMID: 20054525; PubMed Central PMCID: PMC2891391. 20: Yoon SS, Kim H, Choi KH, Lee BH, Lee YK, Lim SC, Choi SH, Hwang M, Kim KJ, Yang CH. Acupuncture suppresses morphine self-administration through the GABA receptors. Brain Res Bull. 2010 Apr 5;81(6):625-30. doi: 10.1016/j.brainresbull.2009.12.011. PubMed PMID: 20043979.

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Diphosphoric acid, ammonium salt

Diphosphoric acid, ammonium salt