UCM53 is a small molecule inhibitor that targets the mitochondrial permeability transition pore (mPTP), a key regulator of mitochondrial membrane permeability. By binding to the mPTP complex, it prevents pore opening, which is typically triggered under conditions of oxidative stress or calcium overload. This mechanism protects against mitochondrial dysfunction, inhibits cytochrome c release, and reduces apoptosis, making it a promising therapeutic candidate for diseases involving mitochondrial damage, such as ischemia-reperfusion injury and neurodegenerative disorders.
MedKoo Cat#: 112128
Name: UCM53
CAS#: 2468847-23-4
Chemical Formula: C24H14Cl2O6
Exact Mass: 468.0167
Molecular Weight: 469.27
Elemental Analysis: C, 61.43; H, 3.01; Cl, 15.11; O, 20.46
The following data is based on the product molecular weight 469.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
