XQ2B | cyclic decapeptide | Aβ | toxic oligomer | CAS#2104728-28-9

MedKoo Cat#: 126329 | Name: XQ2B

Description:

WARNING: This product is for research use only, not for human or veterinary use.

XQ2B is a cyclic decapeptide. XQ2B can inhibit formation of Aβ toxic oligomer, eliminate Aβ plaque in brain, thereby effectively lowering nerve cell damage caused by Aβ (amyloid β protein); and can be used for diagnosing or treating Aβ-related diseases including glaucoma, age-related macular degeneration and Alzheimer's disease.

Chemical Structure

XQ2B

CAS#2104728-28-9

Theoretical Analysis

MedKoo Cat#: 126329

Name: XQ2B

CAS#: 2104728-28-9

Chemical Formula: C59H92N16O11

Exact Mass: 1200.7131

Molecular Weight: 1201.49

Elemental Analysis: C, 58.98; H, 7.72; N, 18.65; O, 14.65

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

XQ2B; XQ-2B; XQ 2B

IUPAC/Chemical Name

2-[3-[(3R,6S,9S,12S,15S,18R,21S,24S,27S,30S)-3,18-dibenzyl-9-[3-(diaminomethylideneamino)propyl]-12-[(1R)-1-hydroxyethyl]-15-methyl-6,21-bis(2-methylpropyl)-2,5,8,11,14,17,20,23,26,29-decaoxo-27-propan-2-yl-1,4,7,10,13,16,19,22,25,28-decazabicyclo[28.3.0]tritriacontan-24-yl]propyl]guanidine

InChi Key

ZKSBDEIRCKGNQT-XXTAEOGISA-N

InChi Code

InChI=1S/C59H92N16O11/c1-32(2)28-41-52(81)71-43(30-37-18-11-9-12-19-37)51(80)66-35(7)48(77)74-47(36(8)76)56(85)68-40(23-16-26-65-59(62)63)50(79)70-42(29-33(3)4)53(82)72-44(31-38-20-13-10-14-21-38)57(86)75-27-17-24-45(75)54(83)73-46(34(5)6)55(84)67-39(49(78)69-41)22-15-25-64-58(60)61/h9-14,18-21,32-36,39-47,76H,15-17,22-31H2,1-8H3,(H,66,80)(H,67,84)(H,68,85)(H,69,78)(H,70,79)(H,71,81)(H,72,82)(H,73,83)(H,74,77)(H4,60,61,64)(H4,62,63,65)/t35-,36+,39-,40-,41-,42-,43+,44+,45-,46-,47-/m0/s1

SMILES Code

N/C(N)=N\CCC[C@H](NC([C@H](C(C)C)N1)=O)C(N[C@@H](CC(C)C)C(N[C@H](CC2=CC=CC=C2)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC/N=C(N)\N)C(N[C@@H](CC(C)C)C(N[C@H](CC3=CC=CC=C3)C(N4CCC[C@@]4([H])C1=O)=O)=O)=O)=O)=O)=O)=O)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,201.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Wang X, Wang Y, Cao A, Luo Q, Chen D, Zhao W, Xu J, Li Q, Bu X, Quan J. Development of cyclopeptide inhibitors of cGAS targeting protein-DNA interaction and phase separation. Nat Commun. 2023 Oct 2;14(1):6132. doi: 10.1038/s41467-023-41892-5. PMID: 37783727; PMCID: PMC10545747.