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MedKoo Cat#: 112123 | Name: Phloroglucinol
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Phloroglucinol induces apoptosis in HT-29 human colon cancer cells and inhibits metastasis of BT549 and MDA-MB-231 human breast cancer cells.

Chemical Structure

Phloroglucinol
Phloroglucinol
CAS#108-73-6

Theoretical Analysis

MedKoo Cat#: 112123

Name: Phloroglucinol

CAS#: 108-73-6

Chemical Formula: C6H6O3

Exact Mass: 126.0317

Molecular Weight: 126.11

Elemental Analysis: C, 57.14; H, 4.80; O, 38.06

Price and Availability

Size Price Availability Quantity
25g USD 330.00 2 Weeks
50g USD 560.00 2 Weeks
100g USD 800.00 2 Weeks
500g USD 1,250.00 2 Weeks
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Related CAS #
No Data
Synonym
Phloroglucinol; Benzene-s-triol; 1,3,5-Hydroxybenzene; NSC 1572; 1,3,5-Trihydroxybenzene; sym-Trihydroxybenzene; NSC1572; NSC-1572
IUPAC/Chemical Name
benzene-1,3,5-triol
InChi Key
QCDYQQDYXPDABM-UHFFFAOYSA-N
InChi Code
InChI=1S/C6H6O3/c7-4-1-5(8)3-6(9)2-4/h1-3,7-9H
SMILES Code
OC1=CC(O)=CC(O)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM comments
Solubility
DMF 30.0 237.89
DMSO 15.0 118.94
Ethanol 25.0 198.24
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 126.11 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chen LY, Luo EE, Pan Y, Liang CQ, Yu MY, Xu-Jie Q. Acetylcholinesterase inhibitory phloroglucinols from tropic Rhodomyrtus tomentosa. Phytochemistry. 2024 Aug 17:114254. doi: 10.1016/j.phytochem.2024.114254. Epub ahead of print. PMID: 39159738. 2: Aggarwal M, Sharda D, Srivastava S, Kotnees DK, Choudhury D, Das P. Carbonized Polymer Dot-Tannic Acid Nanoglue: Tissue Reinforcement with Concurrent Fluorescent Tracking, Insulin Delivery, and Reactive Oxygen Species Regulation for Normal and Diabetic Wound Healing. Small. 2024 Aug 15:e2405531. doi: 10.1002/smll.202405531. Epub ahead of print. PMID: 39148199. 3: Brown D, Barraco M, Benes NE, Neyertz S. Development of All-Atom Empirical Potentials for Phloroglucinol (Phg) and Hexachlorocyclotriphosphazene (HCCP) Based on their Crystal Phase Structures. J Phys Chem A. 2024 Aug 22;128(33):7023-7035. doi: 10.1021/acs.jpca.4c03364. Epub 2024 Aug 13. PMID: 39136974. 4: Nie C, Huang X, Xiang T, Wang Z, Zhang X. Discovery and characterization of the PpqI/R quorum sensing system activated by GacS/A and Hfq in Pseudomonas protegens H78. Microbiol Res. 2024 Oct;287:127868. doi: 10.1016/j.micres.2024.127868. Epub 2024 Aug 6. PMID: 39126862. 5: Ahmad S, Jan K, Sahu JK, Jan S, Chauhan K, Bashir K. Physicochemical, thermal, and functional properties of edible red algae (Gracilaria corticata). J Food Sci. 2024 Aug 10. doi: 10.1111/1750-3841.17283. Epub ahead of print. PMID: 39126689. 6: Li Q, Feng H, Tian Q, Xiang Y, Wang X, He YX, Zhu K. Discovery of antibacterial diketones against gram-positive bacteria. Cell Chem Biol. 2024 Jul 31:S2451-9456(24)00277-0. doi: 10.1016/j.chembiol.2024.06.017. Epub ahead of print. PMID: 39089260. 7: Stasińska-Jakubas M, Dresler S, Strzemski M, Rubinowska K, Hawrylak-Nowak B. Differentiated response of Hypericum perforatum to foliar application of selected metabolic modulators: Elicitation potential of chitosan, selenium, and salicylic acid mediated by redox imbalance. Phytochemistry. 2024 Jul 26;227:114231. doi: 10.1016/j.phytochem.2024.114231. Epub ahead of print. PMID: 39068961. 8: Sim HH, Shiwakoti S, Lee JH, Lee IY, Ok Y, Lim HK, Ko JY, Oak MH. 2,7-Phloroglucinol-6,6'-bieckol from Ecklonia cava ameliorates nanoplastics- induced premature endothelial senescence and dysfunction. Sci Total Environ. 2024 Nov 1;949:175007. doi: 10.1016/j.scitotenv.2024.175007. Epub 2024 Jul 23. PMID: 39053557. 9: Ahmed H, Fayyaz TB, Khatian N, Usman S, Nisar U, Abid M, Ali SA, Abbas G. Phloroglucinol inhibited glycation via entrapping carbonyl intermediates. PLoS One. 2024 Jul 25;19(7):e0307708. doi: 10.1371/journal.pone.0307708. PMID: 39052603; PMCID: PMC11271877. 10: Fournier J, Barret L, Khouri C, Naudet F, Boussageon R, Roustit M. The evidence base of the 10 most prescribed drugs in England, France, and the United States: a scoping review. J Clin Epidemiol. 2024 Jul 22;174:111478. doi: 10.1016/j.jclinepi.2024.111478. Epub ahead of print. PMID: 39047918. 11: Li Y, Xu T, Tu Y, Li T, Wei Y, Zhou Y. An aldolase-dependent phloroglucinol degradation pathway in Collinsella sp. zg1085. Appl Environ Microbiol. 2024 Aug 21;90(8):e0104724. doi: 10.1128/aem.01047-24. Epub 2024 Jul 19. PMID: 39028195; PMCID: PMC11337842. 12: Piras F, Sogos V, Pollastro F, Rosa A. Protective Effect of Arzanol against H2O2-Induced Oxidative Stress Damage in Differentiated and Undifferentiated SH-SY5Y Cells. Int J Mol Sci. 2024 Jul 5;25(13):7386. doi: 10.3390/ijms25137386. PMID: 39000492; PMCID: PMC11242736. 13: Yamamoto S, Yamamoto S, Takahashi M, Mii A, Okubo A, Toriu N, Nakagawa S, Abe T, Fukuma S, Imamura H, Yamamoto M, Yanagita M. Visualization of intracellular ATP dynamics in different nephron segments under pathophysiological conditions using the kidney slice culture system. Kidney Int. 2024 Sep;106(3):470-481. doi: 10.1016/j.kint.2024.05.028. Epub 2024 Jul 9. PMID: 38996810. 14: Park GB, Yang HL, Kim JM, Jung H, Baek G, Park CK, Park JS. Synthesis of low-k SiONC thin films by plasma-assisted molecular layer deposition with tetraisocyanatesilane and phloroglucinol. Nanotechnology. 2024 Jul 18;35(40). doi: 10.1088/1361-6528/ad60cd. PMID: 38981456. 15: Carecho R, Marques D, Carregosa D, Masuero D, Garcia-Aloy M, Tramer F, Passamonti S, Vrhovsek U, Ventura MR, Brito MA, Nunes Dos Santos C, Figueira I. Circulating low-molecular-weight (poly)phenol metabolites in the brain: unveiling in vitro and in vivo blood-brain barrier transport. Food Funct. 2024 Jul 29;15(15):7812-7827. doi: 10.1039/d4fo01396d. PMID: 38967492. 16: Wiese L, Kolbe SM, Weber M, Ludlow M, Christmann M. Synthesis and biological evaluation of cleistocaltone A, an inhibitor of respiratory syncytial virus (RSV). Chem Sci. 2024 May 24;15(26):10121-10125. doi: 10.1039/d4sc01897d. PMID: 38966381; PMCID: PMC11220581. 17: Mansoor R, Hasan Z, Zaidan Y. ANTICANCER ACTIVITY OF PHLORETIN COMPOUND PURIFIED FROM IRAQI MALUS DOMESTICA L. (APPLE) LEAVES. Georgian Med News. 2024 Apr;(349):126-136. PMID: 38963216. 18: Zaman S, Khan N, Zahoor M, Ullah R, Bari A, Sohail. Phytochemical-mediated regulation of aflatoxigenic fungi contamination in a shifting climate and environment. Environ Geochem Health. 2024 Jul 3;46(8):272. doi: 10.1007/s10653-024-02045-9. PMID: 38958785. 19: Pantusa C, Rinaldi M, Salamone S, Sanna C, Allegrone G, Pollastro F. Helichrysum microphyllum subsp. tyrrhenicum: a possible correlation between small volatile compounds and phloroglucinol content. Nat Prod Res. 2024 Jun 27:1-9. doi: 10.1080/14786419.2024.2371565. Epub ahead of print. PMID: 38934732. 20: Marković ZM, Milivojević DD, Kovač J, Todorović Marković BM. Phloroglucinol- Based Carbon Quantum Dots/Polyurethane Composite Films: How Structure of Carbon Quantum Dots Affects Antibacterial and Antibiofouling Efficiency of Composite Films. Polymers (Basel). 2024 Jun 11;16(12):1646. doi: 10.3390/polym16121646. PMID: 38931997; PMCID: PMC11207477.