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MedKoo Cat#: 562087 | Name: AM-8735

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AM-8735 is a selective and potent inhibitor of the MDM2-p53 protein-protein interaction.

Chemical Structure

AM-8735
AM-8735
CAS#1429386-01-5

Theoretical Analysis

MedKoo Cat#: 562087

Name: AM-8735

CAS#: 1429386-01-5

Chemical Formula: C27H31Cl2NO7S

Exact Mass: 583.1198

Molecular Weight: 584.50

Elemental Analysis: C, 55.48; H, 5.35; Cl, 12.13; N, 2.40; O, 19.16; S, 5.48

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AM-8735; AM 8735; AM8735;
IUPAC/Chemical Name
2-[(2R,5R,6R)-6-(3-Chlorophenyl)-5-(4-chlorophenyl)-4-[(1S)-1-cyclopropyl-2-[(2-methylpropan-2-yl)oxysulfonyl]ethyl]-3-oxomorpholin-2-yl]acetic acid
InChi Key
HYGVYNHGIBTUSG-WMMXXEOUSA-N
InChi Code
InChI=1S/C27H31Cl2NO7S/c1-27(2,3)37-38(34,35)15-21(16-7-8-16)30-24(17-9-11-19(28)12-10-17)25(18-5-4-6-20(29)13-18)36-22(26(30)33)14-23(31)32/h4-6,9-13,16,21-22,24-25H,7-8,14-15H2,1-3H3,(H,31,32)/t21-,22-,24-,25-/m1/s1
SMILES Code
O=C(O)C[C@@H]1C(N([C@@H](C2CC2)CS(=O)(OC(C)(C)C)=O)[C@H](C3=CC=C(Cl)C=C3)[C@@H](C4=CC=CC(Cl)=C4)O1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 584.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gonzalez AZ, Eksterowicz J, Bartberger MD, Beck HP, Canon J, Chen A, Chow D, Duquette J, Fox BM, Fu J, Huang X, Houze JB, Jin L, Li Y, Li Z, Ling Y, Lo MC, Long AM, McGee LR, McIntosh J, McMinn DL, Oliner JD, Osgood T, Rew Y, Saiki AY, Shaffer P, Wortman S, Yakowec P, Yan X, Ye Q, Yu D, Zhao X, Zhou J, Olson SH, Medina JC, Sun D. Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction. J Med Chem. 2014 Mar 27;57(6):2472-88. doi: 10.1021/jm401767k. Epub 2014 Mar 4. PubMed PMID: 24548297.