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MedKoo Cat#: 112119 | Name: Retinyl Palmitate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Retinyl palmitate is a major storage form of vitamin A in vivo and is cytotoxic to HeLa cells.

Chemical Structure

Retinyl Palmitate
Retinyl Palmitate
CAS#79-81-2

Theoretical Analysis

MedKoo Cat#: 112119

Name: Retinyl Palmitate

CAS#: 79-81-2

Chemical Formula: C36H60O2

Exact Mass: 524.4593

Molecular Weight: 524.87

Elemental Analysis: C, 82.38; H, 11.52; O, 6.10

Price and Availability

Size Price Availability Quantity
5g USD 260.00 2 Weeks
10g USD 500.00 2 Weeks
25g USD 800.00 2 Weeks
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Related CAS #
No Data
Synonym
Retinyl Palmitate; all-trans Retinyl Palmitate; Vitamin A Palmitate
IUPAC/Chemical Name
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-yl palmitate
InChi Key
VYGQUTWHTHXGQB-FFHKNEKCSA-N
InChi Code
InChI=1S/C36H60O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-25-35(37)38-30-28-32(3)23-20-22-31(2)26-27-34-33(4)24-21-29-36(34,5)6/h20,22-23,26-28H,7-19,21,24-25,29-30H2,1-6H3/b23-20+,27-26+,31-22+,32-28+
SMILES Code
CC1=C(C(C)(CCC1)C)/C=C/C(C)=C/C=C/C(C)=C/COC(CCCCCCCCCCCCCCC)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
DMF 5.0 9.53
DMSO 5.0 9.53
Ethanol 15.0 28.63
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 524.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: de Carvalho RM, Aguiar RPS, Islam MT, de Alencar MVOB, da Mata AMOF, Braga AL, Júnior JJDS, Sousa LDR, de Lima RMT, Paz MFCJ, E Sousa JMC, Melo-Cavalcante AAC. Cytogenotoxicological defense of retinyl palmitate in the front damage of antineoplastics. Exp Toxicol Pathol. 2017 Jun 14;69(5):293-297. doi: 10.1016/j.etp.2017.01.013. Epub 2017 Feb 16. PMID: 28216169. 2: Moulas AN, Gerogianni IC, Papadopoulos D, Gourgoulianis KI. Serum retinoic acid, retinol and retinyl palmitate levels in patients with lung cancer. Respirology. 2006 Mar;11(2):169-74. doi: 10.1111/j.1440-1843.2006.00833.x. PMID: 16548902. 3: De Luca LM, Brugh M, Silverman-Jones CS. Retinyl palmitate, retinyl phosphate, and dolichyl phosphate of postnuclear membrane fraction from hepatoma, host liver, and regenerating liver: marginal vitamin A status of hepatoma tissue. Cancer Res. 1984 Jan;44(1):224-32. PMID: 6690036. 4: Ibrahim T, Rouby MNE, Al-Sherbini EAM, Noury AHE, Morsy ME. Photodecomposition, photomutagenicity and photocytotoxicity of retinyl palmitate under He-Ne laser photoirradiation and its effects on photodynamic therapy of cancer cells in vitro. Photodiagnosis Photodyn Ther. 2016 Mar;13:316-322. doi: 10.1016/j.pdpdt.2015.09.002. Epub 2015 Sep 10. PMID: 26365099. 5: Copper MP, Klaassen I, Teerlink T, Snow GB, Braakhuis BJ. Plasma retinoid levels in head and neck cancer patients: a comparison with healthy controls and the effect of retinyl palmitate treatment. Oral Oncol. 1999 Jan;35(1):40-4. doi: 10.1016/s1368-8375(98)00084-0. PMID: 10211309. 6: Goodman GE, Thornquist M, Kestin M, Metch B, Anderson G, Omenn GS. The association between participant characteristics and serum concentrations of beta-carotene, retinol, retinyl palmitate, and alpha-tocopherol among participants in the Carotene and Retinol Efficacy Trial (CARET) for prevention of lung cancer. Cancer Epidemiol Biomarkers Prev. 1996 Oct;5(10):815-21. PMID: 8896893. 7: Gensler HL, Watson RR, Moriguchi S, Bowden GT. Effects of dietary retinyl palmitate or 13-cis-retinoic acid on the promotion of tumors in mouse skin. Cancer Res. 1987 Feb 15;47(4):967-70. PMID: 3467842. 8: Mei N, Xia Q, Chen L, Moore MM, Fu PP, Chen T. Photomutagenicity of retinyl palmitate by ultraviolet a irradiation in mouse lymphoma cells. Toxicol Sci. 2005 Nov;88(1):142-9. doi: 10.1093/toxsci/kfi291. Epub 2005 Aug 17. PMID: 16107546; PMCID: PMC6370028. 9: McDaniel SM, O'Neill C, Metz RP, Tarbutton E, Stacewicz-Sapuntzakis M, Heimendinger J, Wolfe P, Thompson H, Schedin P. Whole-food sources of vitamin A more effectively inhibit female rat sexual maturation, mammary gland development, and mammary carcinogenesis than retinyl palmitate. J Nutr. 2007 Jun;137(6):1415-22. doi: 10.1093/jn/137.6.1415. PMID: 17513400. 10: Kalman DA, Goodman GE, Omenn GS, Bellamy G, Rollins B. Micronutrient assay for cancer prevention clinical trials: serum retinol, retinyl palmitate, alpha- carotene, and beta-carotene with the use of high-performance liquid chromatography. J Natl Cancer Inst. 1987 Nov;79(5):975-82. PMID: 3479646.

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AC2P36

AC2P36