|
Solvent |
mg/mL |
mM |
| Solubility |
| DMF |
30.0 |
78.87 |
| DMSO |
30.0 |
78.87 |
| Ethanol |
0.2 |
0.53 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
380.36
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Pradhan P, Nguyen ML. Herpes simplex virus virucidal activity of MST-312 and epigallocatechin gallate. Virus Res. 2018 Apr 2;249:93-98. doi: 10.1016/j.virusres.2018.03.015. Epub 2018 Mar 28. PMID: 29604359.
2: Wang SJ, Yang PM. A Bioinformatics Analysis Identifies the Telomerase Inhibitor MST-312 for Treating High-STMN1-Expressing Hepatocellular Carcinoma. J Pers Med. 2021 Apr 22;11(5):332. doi: 10.3390/jpm11050332. PMID: 33922244; PMCID: PMC8145764.
3: Gurung RL, Lim SN, Low GK, Hande MP. MST-312 Alters Telomere Dynamics, Gene Expression Profiles and Growth in Human Breast Cancer Cells. J Nutrigenet Nutrigenomics. 2014;7(4-6):283-98. doi: 10.1159/000381346. Epub 2015 May 27. PMID: 26022559.
4: Ameri Z, Ghiasi S, Farsinejad A, Hassanshahi G, Ehsan M, Fatemi A. Telomerase inhibitor MST-312 induces apoptosis of multiple myeloma cells and down- regulation of anti-apoptotic, proliferative and inflammatory genes. Life Sci. 2019 Jul 1;228:66-71. doi: 10.1016/j.lfs.2019.04.060. Epub 2019 Apr 25. PMID: 31029779.
5: Haberichter J, Roberts S, Abbasi I, Dedthanou P, Pradhan P, Nguyen ML. The Telomerase Inhibitor MST-312 Interferes with Multiple Steps in the Herpes Simplex Virus Life Cycle. J Virol. 2015 Oct;89(19):9804-16. doi: 10.1128/JVI.01006-15. Epub 2015 Jul 15. PMID: 26178994; PMCID: PMC4577908.
6: Fatemi A, Safa M, Kazemi A. MST-312 induces G2/M cell cycle arrest and apoptosis in APL cells through inhibition of telomerase activity and suppression of NF-κB pathway. Tumour Biol. 2015 Nov;36(11):8425-37. doi: 10.1007/s13277-015-3575-z. Epub 2015 May 29. PMID: 26022158.
7: Ghasemimehr N, Farsinejad A, Mirzaee Khalilabadi R, Yazdani Z, Fatemi A. The telomerase inhibitor MST-312 synergistically enhances the apoptotic effect of doxorubicin in pre-B acute lymphoblastic leukemia cells. Biomed Pharmacother. 2018 Oct;106:1742-1750. doi: 10.1016/j.biopha.2018.07.140. Epub 2018 Jul 30. PMID: 30170357.
8: Morais KS, Guimarãesb AFR, Ramos DAR, Silva FP, de Oliveira DM. Long-term exposure to MST-312 leads to telomerase reverse transcriptase overexpression in MCF-7 breast cancer cells. Anticancer Drugs. 2017 Aug;28(7):750-756. doi: 10.1097/CAD.0000000000000508. PMID: 28520570.
9: Seimiya H, Oh-hara T, Suzuki T, Naasani I, Shimazaki T, Tsuchiya K, Tsuruo T. Telomere shortening and growth inhibition of human cancer cells by novel synthetic telomerase inhibitors MST-312, MST-295, and MST-1991. Mol Cancer Ther. 2002 Jul;1(9):657-65. PMID: 12479362.
10: Chung SS, Oliva B, Dwabe S, Vadgama JV. Combination treatment with flavonoid morin and telomerase inhibitor MST‑312 reduces cancer stem cell traits by targeting STAT3 and telomerase. Int J Oncol. 2016 Aug;49(2):487-98. doi: 10.3892/ijo.2016.3546. Epub 2016 May 31. PMID: 27279256; PMCID: PMC4922839.
11: Morais KDS, Arcanjo DDS, de Faria Lopes GP, da Silva GG, da Mota THA, Gabriel TR, Rabello Ramos DDA, Silva FP, de Oliveira DM. Long-term in vitro treatment with telomerase inhibitor MST-312 induces resistance by selecting long telomeres cells. Cell Biochem Funct. 2019 Jun;37(4):273-280. doi: 10.1002/cbf.3398. Epub 2019 Apr 23. PMID: 31012504.
12: Wang Y, Sun C, Mao A, Zhang X, Zhou X, Wang Z, Zhang H. Radiosensitization to X-ray radiation by telomerase inhibitor MST-312 in human hepatoma HepG2 cells. Life Sci. 2015 Feb 15;123:43-50. doi: 10.1016/j.lfs.2014.12.027. Epub 2015 Jan 13. PMID: 25596016.
