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MedKoo Cat#: 556094 | Name: TTK21
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TTK21 is an activator of CBP/p300 histone acetyltransferase activity.

Chemical Structure

TTK21
TTK21
CAS#709676-56-2

Theoretical Analysis

MedKoo Cat#: 556094

Name: TTK21

CAS#: 709676-56-2

Chemical Formula: C17H15ClF3NO2

Exact Mass: 357.0743

Molecular Weight: 357.76

Elemental Analysis: C, 57.07; H, 4.23; Cl, 9.91; F, 15.93; N, 3.92; O, 8.94

Price and Availability

Size Price Availability Quantity
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
200mg USD 1,250.00 2 Weeks
500mg USD 2,650.00 2 Weeks
1g USD 3,650.00 2 Weeks
2g USD 5,950.00 2 Weeks
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Related CAS #
No Data
Synonym
TTK21; TTK-21; TTK 21;
IUPAC/Chemical Name
N-[4-chloro-3-(trifluoromethyl)phenyl]-2-propoxy-benzamide
InChi Key
AQJBXYBDNZHZRE-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H15ClF3NO2/c1-2-9-24-15-6-4-3-5-12(15)16(23)22-11-7-8-14(18)13(10-11)17(19,20)21/h3-8,10H,2,9H2,1H3,(H,22,23)
SMILES Code
O=C(NC1=CC=C(Cl)C(C(F)(F)F)=C1)C2=CC=CC=C2OCCC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
1: Hutson TH, Kathe C, Palmisano I, Bartholdi K, Hervera A, De Virgiliis F, McLachlan E, Zhou L, Kong G, Barraud Q, Danzi MC, Medrano-Fernandez A, Lopez- Atalaya JP, Boutillier AL, Sinha SH, Singh AK, Chaturbedy P, Moon LDF, Kundu TK, Bixby JL, Lemmon VP, Barco A, Courtine G, Di Giovanni S. Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models. Sci Transl Med. 2019 Apr 10;11(487):eaaw2064. doi: 10.1126/scitranslmed.aaw2064. PMID: 30971452; PMCID: PMC7355732. 2: Chatterjee S, Cassel R, Schneider-Anthony A, Merienne K, Cosquer B, Tzeplaeff L, Halder Sinha S, Kumar M, Chaturbedy P, Eswaramoorthy M, Le Gras S, Keime C, Bousiges O, Dutar P, Petsophonsakul P, Rampon C, Cassel JC, Buée L, Blum D, Kundu TK, Boutillier AL. Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator. EMBO Mol Med. 2018 Nov;10(11):e8587. doi: 10.15252/emmm.201708587. PMID: 30275019; PMCID: PMC6220301. 3: Chatterjee S, Mizar P, Cassel R, Neidl R, Selvi BR, Mohankrishna DV, Vedamurthy BM, Schneider A, Bousiges O, Mathis C, Cassel JC, Eswaramoorthy M, Kundu TK, Boutillier AL. A novel activator of CBP/p300 acetyltransferases promotes neurogenesis and extends memory duration in adult mice. J Neurosci. 2013 Jun 26;33(26):10698-712. doi: 10.1523/JNEUROSCI.5772-12.2013. PMID: 23804093; PMCID: PMC6618502.

Preparing Stock Solutions

The following data is based on the product molecular weight 357.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: A S S, Singh AK, P R JL, Bhatt R, Mishra P, Eswaramoorthy M, Banerjee S, Kundu TK. p300/CBP KATs Are Critical for Maturation and Differentiation of Adult Neural Progenitors. ACS Chem Biol. 2024 Nov 15;19(11):2345-2358. doi: 10.1021/acschembio.4c00465. Epub 2024 Sep 24. PMID: 39317967. 2: Singh AK, Rai A, Joshi I, Reddy DN, Guha R, Alka K, Shukla S, Rath SK, Nazir A, Clement JP, Kundu TK. Oral Administration of a Specific p300/CBP Lysine Acetyltransferase Activator Induces Synaptic Plasticity and Repairs Spinal Cord Injury. ACS Chem Neurosci. 2024 Aug 7;15(15):2741-2755. doi: 10.1021/acschemneuro.4c00124. Epub 2024 May 25. PMID: 38795032. 3: Paiva I, Seguin J, Grgurina I, Singh AK, Cosquer B, Plassard D, Tzeplaeff L, Le Gras S, Cotellessa L, Decraene C, Gambi J, Alcala-Vida R, Eswaramoorthy M, Buée L, Cassel JC, Giacobini P, Blum D, Merienne K, Kundu TK, Boutillier AL. Dysregulated expression of cholesterol biosynthetic genes in Alzheimer's disease alters epigenomic signatures of hippocampal neurons. Neurobiol Dis. 2024 Aug;198:106538. doi: 10.1016/j.nbd.2024.106538. Epub 2024 May 22. PMID: 38789057. 4: Nakayama T, Singh AK, Fukutomi T, Uchida N, Terao Y, Hamada H, Muraoka T, Muthusamy E, Kundu TK, Akagawa K. Activator of KAT3 histone acetyltransferase family ameliorates a neurodevelopmental disorder phenotype in the syntaxin 1A ablated mouse model. Cell Rep. 2024 Apr 23;43(4):114101. doi: 10.1016/j.celrep.2024.114101. Epub 2024 Apr 11. PMID: 38613786. 5: Müller F, De Virgiliis F, Kong G, Zhou L, Serger E, Chadwick J, Sanchez- Vassopoulos A, Singh AK, Eswaramoorthy M, Kundu TK, Di Giovanni S. CBP/p300 activation promotes axon growth, sprouting, and synaptic plasticity in chronic experimental spinal cord injury with severe disability. PLoS Biol. 2022 Sep 20;20(9):e3001310. doi: 10.1371/journal.pbio.3001310. PMID: 36126035; PMCID: PMC9488786. 6: Singh AK, Neo SH, Liwang C, Pang KKL, Leng JCK, Sinha SH, Shetty MS, Vasudevan M, Rao VJ, Joshi I, Eswaramoorthy M, Pavon MV, Sheila AR, Navakkode S, Kundu TK, Sajikumar S. Glucose derived carbon nanosphere (CSP) conjugated TTK21, an activator of the histone acetyltransferases CBP/p300, ameliorates amyloid- beta 1-42 induced deficits in plasticity and associativity in hippocampal CA1 pyramidal neurons. Aging Cell. 2022 Sep;21(9):e13675. doi: 10.1111/acel.13675. Epub 2022 Aug 12. PMID: 35962576; PMCID: PMC9470894. 7: Hutson TH, Kathe C, Palmisano I, Bartholdi K, Hervera A, De Virgiliis F, McLachlan E, Zhou L, Kong G, Barraud Q, Danzi MC, Medrano-Fernandez A, Lopez- Atalaya JP, Boutillier AL, Sinha SH, Singh AK, Chaturbedy P, Moon LDF, Kundu TK, Bixby JL, Lemmon VP, Barco A, Courtine G, Di Giovanni S. Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models. Sci Transl Med. 2019 Apr 10;11(487):eaaw2064. doi: 10.1126/scitranslmed.aaw2064. PMID: 30971452; PMCID: PMC7355732. 8: Chatterjee S, Cassel R, Schneider-Anthony A, Merienne K, Cosquer B, Tzeplaeff L, Halder Sinha S, Kumar M, Chaturbedy P, Eswaramoorthy M, Le Gras S, Keime C, Bousiges O, Dutar P, Petsophonsakul P, Rampon C, Cassel JC, Buée L, Blum D, Kundu TK, Boutillier AL. Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator. EMBO Mol Med. 2018 Nov;10(11):e8587. doi: 10.15252/emmm.201708587. PMID: 30275019; PMCID: PMC6220301. 9: Chatterjee S, Mizar P, Cassel R, Neidl R, Selvi BR, Mohankrishna DV, Vedamurthy BM, Schneider A, Bousiges O, Mathis C, Cassel JC, Eswaramoorthy M, Kundu TK, Boutillier AL. A novel activator of CBP/p300 acetyltransferases promotes neurogenesis and extends memory duration in adult mice. J Neurosci. 2013 Jun 26;33(26):10698-712. doi: 10.1523/JNEUROSCI.5772-12.2013. PMID: 23804093; PMCID: PMC6618502.