MedKoo Cat#: 556093 | Name: NTNCB HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

NTNCB is a selective, non-peptide competitive NPY Y5 antagonist. NTNCB potently antagonizes NPY inhibition of forskolin-stimulated cAMP. NTNCB Displays some affinity for cloned human D2 and α2C receptors (Ki values are 63 and 100 nM respectively).

Chemical Structure

NTNCB HCl
NTNCB HCl
CAS#191931-56-3 (HCl)

Theoretical Analysis

MedKoo Cat#: 556093

Name: NTNCB HCl

CAS#: 191931-56-3 (HCl)

Chemical Formula: C25H34ClN3O4S

Exact Mass: 0.0000

Molecular Weight: 508.07

Elemental Analysis: C, 59.10; H, 6.75; Cl, 6.98; N, 8.27; O, 12.60; S, 6.31

Price and Availability

Size Price Availability Quantity
100mg USD 1,350.00 2 Weeks
200mg USD 1,950.00 2 Weeks
500mg USD 3,650.00 2 Weeks
1g USD 4,950.00 2 Weeks
2g USD 7,950.00 2 Weeks
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Related CAS #
486453-65-0 (free base) 191931-56-3 (HCl)
Synonym
NTNCB HCl; NTNCB hydrochloride;
IUPAC/Chemical Name
2-Nitro-N-[[trans-4-[[[(1,2,3,4-tetrahydro-2-naphthalenyl)methyl]amino]methyl]cyclohexyl]methyl]benzenesulfonamide hydrochloride
InChi Key
BKCQHNDMUNWNQC-GEIALWGYSA-N
InChi Code
InChI=1S/C25H33N3O4S.ClH/c29-28(30)24-7-3-4-8-25(24)33(31,32)27-18-20-11-9-19(10-12-20)16-26-17-21-13-14-22-5-1-2-6-23(22)15-21;/h1-8,19-21,26-27H,9-18H2;1H/t19-,20-,21?;
SMILES Code
O=S(C1=CC=CC=C1[N+]([O-])=O)(NC[C@H]2CC[C@H](CNCC3CC4=C(C=CC=C4)CC3)CC2)=O.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 508.07 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Islam I, Dhanoa D, Finn J, Du P, Walker MW, Salon JA, Zhang J, Gluchowski C. Discovery of potent and selective small molecule NPY Y5 receptor antagonists. Bioorg Med Chem Lett. 2002 Jul 8;12(13):1767-9. doi: 10.1016/s0960-894x(02)00287-1. PMID: 12067557.