SLF1081851 is an In Vivo Active Sphingosine-1-phosphate Transporter (Spns2) Inhibitor. In vitro studies in HeLa cells demonstrated that SLF1081851 inhibited S1P release with an IC50 of 1.93 μM. Administration of SLF1081851 to mice and rats drove significant decreases in circulating lymphocyte counts and plasma S1P concentrations, recapitulating the phenotype observed in mice made deficient in Spns2.
MedKoo Cat#: 466283
Name: SLF1081851
CAS#: 2763730-97-6 (free base)
Chemical Formula: C21H33N3O
Exact Mass: 343.2624
Molecular Weight: 343.52
Elemental Analysis: C, 73.43; H, 9.68; N, 12.23; O, 4.66
The following data is based on the product molecular weight 343.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
