KCa2 Positive Modulator 2q | CAS# | Positive modulator

MedKoo Cat#: 208113 | Name: KCa2 Positive Modulator 2q

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KCa2 Positive Modulator 2q is a subtype selective positive KCa2 channel positive modulator.

Chemical Structure

KCa2 Positive Modulator 2q

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 208113

Name: KCa2 Positive Modulator 2q

CAS#: N/A

Chemical Formula: C16H15ClFN5

Exact Mass: 331.1000

Molecular Weight: 331.78

Elemental Analysis: C, 57.92; H, 4.56; Cl, 10.68; F, 5.73; N, 21.11

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

KCa2 Positive Modulator 2q; KCa2Positive Modulator2q; KCa2-Positive-Modulator-2q

IUPAC/Chemical Name

N-(5-chloro-2-fluorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-amine

InChi Key

DWOQPNHOXLUTJZ-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H15ClFN5/c1-9-7-15(20-14-8-12(17)4-5-13(14)18)21-16(19-9)23-11(3)6-10(2)22-23/h4-8H,1-3H3,(H,19,20,21)

SMILES Code

CC1=NN(C2=NC(NC3=CC(Cl)=CC=C3F)=CC(C)=N2)C(C)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 331.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. El-Sayed NS, Nam YW, Egorova PA, Nguyen HM, Orfali R, Rahman MA, Yang G, Wulff H, Bezprozvanny I, Parang K, Zhang M. Structure-Activity Relationship Study of Subtype-Selective Positive Modulators of KCa2 Channels. J Med Chem. 2022 Jan 13;65(1):303-322. doi: 10.1021/acs.jmedchem.1c01473. Epub 2021 Dec 28. PMID: 34962403; PMCID: PMC8758555.