KCO-912 |CAS# 185695-83-4 |ATP-dependent K channel opener

MedKoo Cat#: 530221 | Name: KCO-912

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KCO-912 is an ATP-dependent K channel opener potentially for the treatment of asthma. It is a potent and selective opener of ATP-dependent potassium (K ATP) channels which suppresses airways hyperreactivity at doses devoid of cardiovascular effects.

Chemical Structure

KCO-912

CAS#185695-83-4

Theoretical Analysis

MedKoo Cat#: 530221

Name: KCO-912

CAS#: 185695-83-4

Chemical Formula: C22H26N2O5S

Exact Mass: 430.1562

Molecular Weight: 430.52

Elemental Analysis: C, 61.38; H, 6.09; N, 6.51; O, 18.58; S, 7.45

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

KCO-912; KCO 912; KCO912

IUPAC/Chemical Name

(3S,4R)-3-hydroxy-2,2-dimethyl-4-(2-oxopiperidin-1-yl)-N-phenylchromane-6-sulfonamide

InChi Key

GPTKKIOZEZUGBH-RTWAWAEBSA-N

InChi Code

InChI=1S/C22H26N2O5S/c1-22(2)21(26)20(24-13-7-6-10-19(24)25)17-14-16(11-12-18(17)29-22)30(27,28)23-15-8-4-3-5-9-15/h3-5,8-9,11-12,14,20-21,23,26H,6-7,10,13H2,1-2H3/t20-,21+/m1/s1

SMILES Code

O=S(C1=CC=C2C([C@@H](N3C(CCCC3)=O)[C@H](O)C(C)(C)O2)=C1)(NC4=CC=CC=C4)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 430.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: El-Hashim AZ, Buchheit KH, Fozard J, Page C. Effect of the K+(ATP) channel opener, KCO912, on baseline and allergen induced airway hyperresponsiveness in allergic rabbits. Eur J Pharmacol. 2004 Jan 26;484(2-3):351-6. PubMed PMID: 14744622. 2: Buchheit KH, Manley PW, Quast U, Russ U, Mazzoni L, Fozard JR. KCO912: a potent and selective opener of ATP-dependent potassium (K(ATP)) channels which suppresses airways hyperreactivity at doses devoid of cardiovascular effects. Naunyn Schmiedebergs Arch Pharmacol. 2002 Mar;365(3):220-30. PubMed PMID: 11882918. 3: Black KL, Yin D, Konda BM, Wang X, Hu J, Ko MK, Bayan JA, Sacapano MR, Espinoza AJ, Ong JM, Irvin D, Shu Y. Different effects of KCa and KATP agonists on brain tumor permeability between syngeneic and allogeneic rat models. Brain Res. 2008 Aug 28;1227:198-206. doi: 10.1016/j.brainres.2008.06.046. PubMed PMID: 18602898; PubMed Central PMCID: PMC2605468.