DI-1548 is a novel potent, selective and covalent DCN1 inhibitor. DI-1548 is highly potent and effective in inhibition of the neddylation of cullin 3 in cells with different tissue types, such as osteosarcoma U2OS cell line , immortalized THLE2 liver cells (Fig. 6b), breast cancer MDA-MB-231 cell line, esophageal cancer KYSE70 cell line , and colon cancer HCT116 cell lines. DI-1548 at concentrations as low as 0.3 nM significantly reduce the level of neddylated cullin 3 and achieve profound inhibition of the neddylation of cullin 3 at 1–3 nM.
MedKoo Cat#: 208111
Name: DI-1548
CAS#: 2247060-97-3
Chemical Formula: C32H47N5O4S
Exact Mass: 597.3349
Molecular Weight: 597.82
Elemental Analysis: C, 64.29; H, 7.92; N, 11.72; O, 10.70; S, 5.36
The following data is based on the product molecular weight 597.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
