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MedKoo Cat#: 556090 | Name: MM41
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MM41 is a potent stabilizer of human telomeric and gene promoter DNA quadruplexes.

Chemical Structure

MM41
CAS#1429028-96-5

Theoretical Analysis

MedKoo Cat#: 556090

Name: MM41

CAS#: 1429028-96-5

Chemical Formula: C44H66N10O

Exact Mass: 830.5167

Molecular Weight: 831.08

Elemental Analysis: C, 63.59; H, 8.01; N, 16.85; O, 11.55

Price and Availability

Size Price Availability Quantity
5mg USD 550.00 2 Weeks
10mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
MM41; MM-41; MM 41;
IUPAC/Chemical Name
4,9-bis((3-(4-methylpiperazin-1-yl)propyl)amino)-2,7-bis(3-morpholinopropyl)benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetraone
InChi Key
JOVJRDSWNCUWBX-UHFFFAOYSA-N
InChi Code
InChI=1S/C44H66N10O6/c1-47-15-19-49(20-16-47)9-3-7-45-35-31-33-38-37-34(42(56)53(43(57)39(35)37)13-5-11-51-23-27-59-28-24-51)32-36(46-8-4-10-50-21-17-48(2)18-22-50)40(38)44(58)54(41(33)55)14-6-12-52-25-29-60-30-26-52/h31-32,45-46H,3-30H2,1-2H3
SMILES Code
CN1CCN(CC1)CCCNC1C=C2C3C(=C(C=C4C=3C=1C(=O)N(CCCN1CCOCC1)C4=O)NCCCN1CCN(C)CC1)C(=O)N(CCCN1CCOCC1)C2=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 831.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Neidle S. Structured Waters Mediate Small Molecule Binding to G-Quadruplex Nucleic Acids. Pharmaceuticals (Basel). 2021 Dec 22;15(1):7. doi: 10.3390/ph15010007. PMID: 35056064; PMCID: PMC8781208. 2: Ohnmacht SA, Marchetti C, Gunaratnam M, Besser RJ, Haider SM, Di Vita G, Lowe HL, Mellinas-Gomez M, Diocou S, Robson M, Šponer J, Islam B, Pedley RB, Hartley JA, Neidle S. A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer. Sci Rep. 2015 Jun 16;5:11385. doi: 10.1038/srep11385. PMID: 26077929; PMCID: PMC4468576. 3: Massicotte P, Snyder T, Stulak J, Baumann Kreuziger L. Ventricular assist device thrombosis: Mind your P's &Q's-Pumps, patients, and pills. J Thorac Cardiovasc Surg. 2017 Jun;153(6):1503-1506. doi: 10.1016/j.jtcvs.2016.09.092. Epub 2016 Nov 22. PMID: 27964986. 4: Neumann HP, Hoegerle S, Manz T, Brenner K, Iliopoulos O. How many pathways to pheochromocytoma? Semin Nephrol. 2002 Mar;22(2):89-99. doi: 10.1053/snep.2002.30207. PMID: 11891502. 5: Hymes KB, Schuck MP, Karpatkin S. Regulation of autoimmune anti-platelet antibody-mediated adhesion of monocytes to platelet GPIIb/GPIIIa: effect of armed monocytes and the Mac-1 receptor. Blood. 1990 May 1;75(9):1813-9. PMID: 2184903. 6: Neumann HP, Bender BU. Genotype-phenotype correlations in von Hippel-Lindau disease. J Intern Med. 1998 Jun;243(6):541-5. doi: 10.1046/j.1365-2796.1998.00336.x. PMID: 9681856. 7: Pavenstädt H, Bek M. Podocyte electrophysiology, in vivo and in vitro. Microsc Res Tech. 2002 May 15;57(4):224-7. doi: 10.1002/jemt.10078. PMID: 12012388. 8: Pavenstädt H. Roles of the podocyte in glomerular function. Am J Physiol Renal Physiol. 2000 Feb;278(2):F173-9. doi: 10.1152/ajprenal.2000.278.2.F173. PMID: 10662721. 9: Massicotte MP, Bauman ME. Commentary: Points to ponder-Perioperative antithrombotic therapy in neonates with congenital heart disease…more harm than good? J Thorac Cardiovasc Surg. 2019 Jun;157(6):2414-2415. doi: 10.1016/j.jtcvs.2019.02.066. Epub 2019 Mar 1. PMID: 30902467. 10: Neumann HP, Riegler P, Huber W, Corradini R, Sessa A, Fontana D, Wetterauer U, Janetschek G. The challenge of kidney lesions in von Hippel-Lindau disease. Contrib Nephrol. 2001;(136):193-207. doi: 10.1159/000060187. PMID: 11688380. 11: Neumann HP, Cybulla M, Shibata H, Oya M, Naruse M, Higashihara E, Terachi T, Ling H, Takami H, Shuin T, Murai M. New genetic causes of pheochromocytoma: current concepts and the clinical relevance. Keio J Med. 2005 Mar;54(1):15-21. doi: 10.2302/kjm.54.15. PMID: 15832076. 12: Raffini L, Massicotte MP. Finding the sweet spot: Titrating unfractionated heparin in children after cardiac surgery to prevent thrombosis and minimize bleeding. J Thorac Cardiovasc Surg. 2018 Jul;156(1):353-354. doi: 10.1016/j.jtcvs.2018.03.043. Epub 2018 Mar 17. PMID: 29655541. 13: Neumann HP, Bender BU, Schultze-Seemann W, Krause T, Altehoefer C, Scheremet R, Orszagh M, Schwarzkopf G, Januszewicz A, Janetschek G, Riegler P. The kidney and von Hippel-Lindau disease: impact of molecular genetic analysis of the VHL gene for clinical management. Contrib Nephrol. 1997;122:102-8. doi: 10.1159/000059876. PMID: 9399049. 14: Neumann HP, Bausch B, McWhinney SR, Bender BU, Gimm O, Franke G, Schipper J, Klisch J, Altehoefer C, Zerres K, Januszewicz A, Eng C, Smith WM, Munk R, Manz T, Glaesker S, Apel TW, Treier M, Reineke M, Walz MK, Hoang-Vu C, Brauckhoff M, Klein-Franke A, Klose P, Schmidt H, Maier-Woelfle M, Peçzkowska M, Szmigielski C, Eng C; Freiburg-Warsaw-Columbus Pheochromocytoma Study Group. Germ-line mutations in nonsyndromic pheochromocytoma. N Engl J Med. 2002 May 9;346(19):1459-66. doi: 10.1056/NEJMoa020152. PMID: 12000816. 15: du Toit J, Goeijenbier M, du Toit C, de Witt P, Koornhof H, Oosthuizen J, Louw VJ, Seftel M, Verburgh E. Predictors of poor haematopoietic stem cell mobilisation in patients with haematological malignancies at a South African centre. Transfus Apher Sci. 2022 Mar 3:103419. doi: 10.1016/j.transci.2022.103419. Epub ahead of print. PMID: 35288051. 16: Königer M, Quaschning T, Wanner C, Schollmeyer P, Krämer-Guth A. Abnormalities in lipoprotein metabolism in hemodialysis patients. Kidney Int Suppl. 1999 Jul;71:S248-50. doi: 10.1046/j.1523-1755.1999.07166.x. PMID: 10412790. 17: Krumme B, Blum U. Imaging of renal artery stenosis. Curr Opin Urol. 1998 Mar;8(2):77-82. doi: 10.1097/00042307-199803000-00002. PMID: 17035846. 18: Rump LC, Jabbari-T J, von Kügelgen I, Oberhauser V. Adenosine mediates nitric-oxide-independent renal vasodilation by activation of A2A receptors. J Hypertens. 1999 Dec;17(12 Pt 2):1987-93. doi: 10.1097/00004872-199917121-00032. PMID: 10703900. 19: Neumann HP, Reincke M, Bender BU, Elsner R, Janetschek G. Preserved adrenocortical function after laparoscopic bilateral adrenal sparing surgery for hereditary pheochromocytoma. J Clin Endocrinol Metab. 1999 Aug;84(8):2608-10. doi: 10.1210/jcem.84.8.5872. PMID: 10443647. 20: Neumann HP, Salzmann M, Bohnert-Iwan B, Mannuelian T, Skerka C, Lenk D, Bender BU, Cybulla M, Riegler P, Königsrainer A, Neyer U, Bock A, Widmer U, Male DA, Franke G, Zipfel PF. Haemolytic uraemic syndrome and mutations of the factor H gene: a registry-based study of German speaking countries. J Med Genet. 2003 Sep;40(9):676-81. doi: 10.1136/jmg.40.9.676. PMID: 12960213; PMCID: PMC1735586.