MM-206 | CAS#1809581-87-0 | STAT3 inhibitor

MedKoo Cat#: 561534 | Name: MM-206

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MM-206 is a cell-permeable, non-cytotoxic naphthalene sulfonamide compound effectively inhibits STAT3 DNA-binding activity.

Chemical Structure

MM-206

CAS#1809581-87-0

Theoretical Analysis

MedKoo Cat#: 561534

Name: MM-206

CAS#: 1809581-87-0

Chemical Formula: C22H12F5NO3S2

Exact Mass: 497.0179

Molecular Weight: 497.45

Elemental Analysis: C, 53.12; H, 2.43; F, 19.10; N, 2.82; O, 9.65; S, 12.89

Price and Availability

Size	Price	Availability
5mg	USD 220.00	2 weeks
10mg	USD 380.00	2 weeks
25mg	USD 760.00	2 weeks

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Related CAS #

No Data

Synonym

MM-206; MM-206; MM206;

IUPAC/Chemical Name

2,3,4,5,6-Pentafluoro-N-[4-hydroxy-3-(phenylthio)-1-naphthalenyl]-benzenesulfonamide

InChi Key

ZXJHEANDHXHGMV-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H12F5NO3S2/c23-16-17(24)19(26)22(20(27)18(16)25)33(30,31)28-14-10-15(32-11-6-2-1-3-7-11)21(29)13-9-5-4-8-12(13)14/h1-10,28-29H

SMILES Code

O=S(C1=C(F)C(F)=C(F)C(F)=C1F)(NC2=C3C=CC=CC3=C(O)C(SC4=CC=CC=C4)=C2)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

MM-206, a STAT3 activity inhibitor, potently inhibits the STAT3 SH2 domain-phosphopeptide interaction with IC50 of 1.2 μM.

In vitro activity:

In the SPR-based competitive binding assay (Fig. 2a), MM-206 had IC50 = 1.2 μM, lower than previous-generation inhibitors such as C188 (IC50 = 7.2 μM) and C188-9 (IC50 = 5.0 μM). The inhibitor MM-206 also inhibits inducible STAT3 phosphorylation in AML cell lines (Fig. 5a,b). Following a 30-minute treatment with MM-206 prior to G-CSF stimulation, all three AML cell lines tested exhibited dose-dependent decreases in STAT3 phosphorylation with IC50 0.8–1.9 μM. Reference: Angew Chem Int Ed Engl. 2015 Oct 26;54(44):13085-9. https://pubmed.ncbi.nlm.nih.gov/26480340/

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMF	25.0	50.26
	DMF:PBS (pH 7.2) (1:8)	0.1	0.22
	DMSO	16.0	32.16

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 497.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

Minus MB, Liu W, Vohidov F, Kasembeli MM, Long X, Krueger MJ, Stevens A, Kolosov MI, Tweardy DJ, Sison EA, Redell MS, Ball ZT. Rhodium(II) Proximity-Labeling Identifies a Novel Target Site on STAT3 for Inhibitors with Potent Anti-Leukemia Activity. Angew Chem Int Ed Engl. 2015 Oct 26;54(44):13085-9. doi: 10.1002/anie.201506889. Epub 2015 Sep 7. PMID: 26480340; PMCID: PMC5041597.

In vitro protocol:

In vivo protocol:

TBD