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MedKoo Cat#: 208098 | Name: Smurf1 inhibitor 1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Smurf1 inhibitor 1 is a inhibitor that promotes bone formation.

Chemical Structure

Smurf1 inhibitor 1
Smurf1 inhibitor 1
CAS#136068-42-3

Theoretical Analysis

MedKoo Cat#: 208098

Name: Smurf1 inhibitor 1

CAS#: 136068-42-3

Chemical Formula: C17H14O4

Exact Mass: 282.0892

Molecular Weight: 282.30

Elemental Analysis: C, 72.33; H, 5.00; O, 22.67

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Smurf1 inhibitor 1; Smurf1inhibitor1; Smurf1-inhibitor-1
IUPAC/Chemical Name
2-(4-cinnamoylphenoxy)acetic acid
InChi Key
QRZMBMJGILTZSR-IZZDOVSWSA-N
InChi Code
InChI=1S/C17H14O4/c18-16(11-6-13-4-2-1-3-5-13)14-7-9-15(10-8-14)21-12-17(19)20/h1-11H,12H2,(H,19,20)/b11-6+
SMILES Code
O=C(C1=CC=C(OCC(O)=O)C=C1)/C=C/C2=CC=CC=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 282.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bian C, Luan Z, Zhang H, Zhang R, Gao J, Wang Y, Li J, Ren H. miR-154-5p Affects the TGFβ1/Smad3 Pathway on the Fibrosis of Diabetic Kidney Disease via Binding E3 Ubiquitin Ligase Smurf1. Oxid Med Cell Longev. 2022 Jan 27;2022:7502632. doi: 10.1155/2022/7502632. PMID: 35126820; PMCID: PMC8814716. 2: Liang M, Li Y, Dai T, Chen C. lncRNA FEZF1-AS1 regulates biological behaviors of cervical cancer by targeting miRNA-1254. Food Sci Nutr. 2021 Jul 14;9(9):4722-4737. doi: 10.1002/fsn3.2315. PMID: 34531986; PMCID: PMC8441442. 3: Ning J, Ye Y, Bu D, Zhao G, Song T, Liu P, Yu W, Wang H, Li H, Ren X, Ying G, Zhao Y, Yu J. Imbalance of TGF-β1/BMP-7 pathways induced by M2-polarized macrophages promotes hepatocellular carcinoma aggressiveness. Mol Ther. 2021 Jun 2;29(6):2067-2087. doi: 10.1016/j.ymthe.2021.02.016. Epub 2021 Feb 15. PMID: 33601054; PMCID: PMC8178441. 4: Gifford CC, Tang J, Costello A, Khakoo NS, Nguyen TQ, Goldschmeding R, Higgins PJ, Samarakoon R. Negative regulators of TGF-β1 signaling in renal fibrosis; pathological mechanisms and novel therapeutic opportunities. Clin Sci (Lond). 2021 Jan 29;135(2):275-303. doi: 10.1042/CS20201213. PMID: 33480423. 5: Wang S, Hou P, Pan W, He W, He DC, Wang H, He H. DDIT3 Targets Innate Immunity via the DDIT3-OTUD1-MAVS Pathway To Promote Bovine Viral Diarrhea Virus Replication. J Virol. 2021 Feb 24;95(6):e02351-20. doi: 10.1128/JVI.02351-20. PMID: 33361422; PMCID: PMC8094964. 6: Kamalakar A, McKinney JM, Salinas Duron D, Amanso AM, Ballestas SA, Drissi H, Willett NJ, Bhattaram P, García AJ, Wood LB, Goudy SL. JAGGED1 stimulates cranial neural crest cell osteoblast commitment pathways and bone regeneration independent of canonical NOTCH signaling. Bone. 2021 Feb;143:115657. doi: 10.1016/j.bone.2020.115657. Epub 2020 Sep 25. PMID: 32980561; PMCID: PMC9035226. 7: Zhang X, Wang D, Liu B, Jin X, Wang X, Pan J, Tu W, Shao Y. IMP3 accelerates the progression of prostate cancer through inhibiting PTEN expression in a SMURF1-dependent way. J Exp Clin Cancer Res. 2020 Sep 16;39(1):190. doi: 10.1186/s13046-020-01657-0. PMID: 32938489; PMCID: PMC7493339. 8: Huang S, Li Y, Wu P, Xiao Y, Duan N, Quan J, Du W. microRNA-148a-3p in extracellular vesicles derived from bone marrow mesenchymal stem cells suppresses SMURF1 to prevent osteonecrosis of femoral head. J Cell Mol Med. 2020 Oct;24(19):11512-11523. doi: 10.1111/jcmm.15766. Epub 2020 Sep 1. PMID: 32871042; PMCID: PMC7576243. 9: Xia Q, Zhang H, Zhang P, Li Y, Xu M, Li X, Li X, Dong L. Oncogenic Smurf1 promotes PTEN wild-type glioblastoma growth by mediating PTEN ubiquitylation. Oncogene. 2020 Sep;39(36):5902-5915. doi: 10.1038/s41388-020-01400-1. Epub 2020 Jul 31. PMID: 32737433. 10: Qian G, Zhu L, Huang C, Liu Y, Ren Y, Ding Y, Qian W, Xu Q, Zheng H, Lv H. Ubiquitin specific protease 5 negatively regulates the IFNs-mediated antiviral activity via targeting SMURF1. Int Immunopharmacol. 2020 Oct;87:106763. doi: 10.1016/j.intimp.2020.106763. Epub 2020 Jul 16. PMID: 32683298. 11: Chu Y, Kang Y, Yan C, Yang C, Zhang T, Huo H, Liu Y. LUBAC and OTULIN regulate autophagy initiation and maturation by mediating the linear ubiquitination and the stabilization of ATG13. Autophagy. 2021 Jul;17(7):1684-1699. doi: 10.1080/15548627.2020.1781393. Epub 2020 Jun 26. PMID: 32543267; PMCID: PMC8354604. 12: Zhang Y, Gu X, Li D, Cai L, Xu Q. METTL3 Regulates Osteoblast Differentiation and Inflammatory Response via Smad Signaling and MAPK Signaling. Int J Mol Sci. 2019 Dec 27;21(1):199. doi: 10.3390/ijms21010199. PMID: 31892163; PMCID: PMC6981640. 13: Chen Z, Sun X, Chen Q, Lan T, Huang K, Xiao H, Lin Z, Yang Y, Liu P, Huang H. Connexin32 ameliorates renal fibrosis in diabetic mice by promoting K48-linked NADPH oxidase 4 polyubiquitination and degradation. Br J Pharmacol. 2020 Jan;177(1):145-160. doi: 10.1111/bph.14853. Epub 2019 Dec 23. PMID: 31465542; PMCID: PMC6976783. 14: Fang Z, Zhu Z, Zhang H, Peng Y, Liu J, Lu H, Li J, Liang L, Xia S, Wang Q, Fu B, Wu K, Zhang L, Ginzburg Y, Liu J, Chen H. GDF11 contributes to hepatic hepcidin (HAMP) inhibition through SMURF1-mediated BMP-SMAD signalling suppression. Br J Haematol. 2020 Jan;188(2):321-331. doi: 10.1111/bjh.16156. Epub 2019 Aug 16. PMID: 31418854; PMCID: PMC7733280. 15: Song MK, Lee JH, Ryoo IG, Lee SH, Ku SK, Kwak MK. Bardoxolone ameliorates TGF-β1-associated renal fibrosis through Nrf2/Smad7 elevation. Free Radic Biol Med. 2019 Jul;138:33-42. doi: 10.1016/j.freeradbiomed.2019.04.033. Epub 2019 May 3. PMID: 31059771. 16: Xu S, Hui L, Yang N, Wang Y, Zhao N, Jiang XJ. Upregulation of microRNA‑194‑5p inhibits hypopharyngeal carcinoma cell proliferation, migration and invasion by targeting SMURF1 via the mTOR signaling pathway. Int J Oncol. 2019 Apr;54(4):1245-1255. doi: 10.3892/ijo.2019.4711. Epub 2019 Feb 4. PMID: 30720112; PMCID: PMC6411369. 17: Feng X, Jia Y, Zhang Y, Ma F, Zhu Y, Hong X, Zhou Q, He R, Zhang H, Jin J, Piao D, Huang H, Li Q, Qiu X, Zhang Z. Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth. Autophagy. 2019 Jul;15(7):1130-1149. doi: 10.1080/15548627.2019.1570063. Epub 2019 Jan 27. PMID: 30686098; PMCID: PMC6613838. 18: Jiang M, Shi L, Yang C, Ge Y, Lin L, Fan H, He Y, Zhang D, Miao Y, Yang L. miR-1254 inhibits cell proliferation, migration, and invasion by down-regulating Smurf1 in gastric cancer. Cell Death Dis. 2019 Jan 10;10(1):32. doi: 10.1038/s41419-018-1262-x. PMID: 30631050; PMCID: PMC6328618. 19: Tian M, Zeng T, Liu M, Han S, Lin H, Lin Q, Li L, Jiang T, Li G, Lin H, Zhang T, Kang Q, Deng X, Wang HR. A cell-based high-throughput screening method based on a ubiquitin-reference technique for identifying modulators of E3 ligases. J Biol Chem. 2019 Feb 22;294(8):2880-2891. doi: 10.1074/jbc.RA118.003822. Epub 2018 Dec 26. PMID: 30587574; PMCID: PMC6393603. 20: Yan C, Su H, Song X, Cao H, Kong L, Cui W. Smad Ubiquitination Regulatory Factor 1 (Smurf1) Promotes Thyroid Cancer Cell Proliferation and Migration via Ubiquitin-Dependent Degradation of Kisspeptin-1. Cell Physiol Biochem. 2018;49(5):2047-2059. doi: 10.1159/000493715. Epub 2018 Sep 21. PMID: 30244247.