MedKoo Cat#: 208091 | Name: ZE132
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

ZE132 is a novel potent PD-1/PD-L1 interaction inhibitor that promotes cytotoxic T-cell tumour infiltration.

Chemical Structure

ZE132
ZE132
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 208091

Name: ZE132

CAS#: N/A

Chemical Formula: C37H41ClN4O7S

Exact Mass: 720.2384

Molecular Weight: 721.27

Elemental Analysis: C, 61.61; H, 5.73; Cl, 4.91; N, 7.77; O, 15.53; S, 4.44

Price and Availability

Size Price Availability Quantity
2mg USD 450.00 2 Weeks
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Related CAS #
No Data
Synonym
ZE132; ZE 132; ZE-132; Z E132; Z-E132
IUPAC/Chemical Name
2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)(3-(dimethylamino)propyl)amino)ethane-1-sulfonic acid
InChi Key
QJSJWFVBDAPNAE-UHFFFAOYSA-N
InChi Code
InChI=1S/C37H41ClN4O7S/c1-26-30(6-4-7-32(26)29-8-9-34-37(18-29)47-14-13-46-34)25-49-36-19-35(48-24-28-16-27(20-39)21-40-22-28)31(17-33(36)38)23-42(11-5-10-41(2)3)12-15-50(43,44)45/h4,6-9,16-19,21-22H,5,10-15,23-25H2,1-3H3,(H,43,44,45)
SMILES Code
CN(CCCN(CCS(=O (O)=O)CC1=C(OCC2=CN=CC(C#N)=C2)C=C(OCC3=CC=CC(C4=CC(OCCO5)=C5C=C4)=C3C)C(Cl)=C1)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 721.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Liu C, Zhou F, Yan Z, Shen L, Zhang X, He F, Wang H, Lu X, Yu K, Zhao Y, Zhu D. Discovery of a novel, potent and selective small-molecule inhibitor of PD-1/PD-L1 interaction with robust in vivo anti-tumour efficacy. Br J Pharmacol. 2021 Jul;178(13):2651-2670. doi: 10.1111/bph.15457. Epub 2021 May 4. PMID: 33768523.