DTP3 is a selective GADD45β/MKK7 inhibitor, which inhibits cancer-selective NF-κB survival pathway. DTP3 specifically kills MM cells, ex vivo and in vivo, ablating MM xenografts in mice, with no apparent adverse effects, nor evident toxicity to healthy cells. DTP3 combines on-target-selective pharmacology, therapeutic anticancer efficacy, favourable drug-like properties, long plasma half-life and good bioavailability, with no target-organs of toxicity and no adverse effects preclusive of its clinical development in oncology, upon daily repeat-dose administration in both rodent and non-rodent species.
MedKoo Cat#: 555974
Name: DTP3 inhibitor
CAS#: 1809784-29-9
Chemical Formula: C26H35N7O5
Exact Mass: 525.2700
Molecular Weight: 525.61
Elemental Analysis: C, 59.41; H, 6.71; N, 18.65; O, 15.22
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 100.0 | 190.26 | |
| Ethanol | 100.0 | 190.26 | |
| Water | 100.0 | 190.26 |
The following data is based on the product molecular weight 525.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
