YM-155 is a survivin inhibitor. It inhibits survivin promoter activity in a reporter assay (IC50 = 0.54 nM). YM-155 (10-1,000 nM) reduces survivin levels and induces apoptosis in PC3 and PPC-1 prostate cancer cells. In vivo, YM-155 (3 and 10 mg/kg) inhibits tumor growth, decreases intratumor survivin levels, and induces tumor regression in a PC3 mouse xenograft model. It reduces tumor volume in a MiaPaCa-2 pancreatic cancer mouse xenograft model. YM-155 also inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) papain-like protease (PLpro; IC50 = 2.47 µM) and reduces the number of viral RNA copies in SARS-CoV-2-infected Vero E6 cells.
MedKoo Cat#: 112004
Name: YM-155 Cl
CAS#: 355406-09-6
Chemical Formula: C20H19ClN4O3
Exact Mass:
Molecular Weight: 398.85
Elemental Analysis: C, 60.23; H, 4.80; Cl, 8.89; N, 14.05; O, 12.03
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| PBS (pH: 7.2) | 5.0 | 12.54 |
The following data is based on the product molecular weight 398.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
