Dup 747 | CAS#142515-44-4 | analgesic

MedKoo Cat#: 461131 | Name: Dup 747

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dup 747 is an analgesic drug that binds with high affinity and selectivity to the kappa-opioid receptor.

Chemical Structure

Dup 747

CAS#142515-44-4

Theoretical Analysis

MedKoo Cat#: 461131

Name: Dup 747

CAS#: 142515-44-4

Chemical Formula: C24H28Cl2N2O2

Exact Mass: 446.1528

Molecular Weight: 447.40

Elemental Analysis: C, 64.43; H, 6.31; Cl, 15.85; N, 6.26; O, 7.15

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Dup 747; Dup-747; Dup747;

IUPAC/Chemical Name

2-(3,4-dichlorophenyl)-N-((1R,2R)-5-methoxy-2-(pyrrolidin-1-yl)-1,2,3,4-tetrahydronaphthalen-1-yl)-N-methylacetamide

InChi Key

SYOPRZWROBOKGX-ZJSXRUAMSA-N

InChi Code

InChI=1S/C24H28Cl2N2O2/c1-27(23(29)15-16-8-10-19(25)20(26)14-16)24-18-6-5-7-22(30-2)17(18)9-11-21(24)28-12-3-4-13-28/h5-8,10,14,21,24H,3-4,9,11-13,15H2,1-2H3/t21-,24-/m1/s1

SMILES Code

Clc1ccc(CC(N(C)[C@H]2[C@H](N3CCCC3)CCc4c2cccc4OC)=O)cc1Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 447.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Holtzman SG, Steinfels GF, Schmidt WK. Assessing spiradoline-like discriminative effects of DuP 747: influence of route of administration. Pharmacol Biochem Behav. 1994 Mar;47(3):487-91. PubMed PMID: 8208766. 2: Raghavan K, Dwivedi A, Campbell GC Jr, Nemeth G, Hussain MA. A spectroscopic investigation of DuP 747 polymorphs. J Pharm Biomed Anal. 1994 Jun;12(6):777-85. PubMed PMID: 7918780. 3: Hussain MA, Wu LS, Koval C, Hurwitz AR. Parenteral formulation of the kappa agonist analgesic, DuP 747, via micellar solubilization. Pharm Res. 1992 Jun;9(6):750-2. PubMed PMID: 1409356. 4: Holtzman SG. Further characterization of the discriminative stimulus effects of spiradoline. Pharmacol Biochem Behav. 2000 Jul;66(3):517-22. PubMed PMID: 10899364.