HDAC6 degrader 14a | CAS# | Anti-cancer therapeutic

MedKoo Cat#: 208051 | Name: HDAC6 degrader 14a

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HDAC6 degrader 14a is a novel PROTAC HDAC6 degrader which is an anti-cancer therapeutic.

Chemical Structure

HDAC6 degrader 14a

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 208051

Name: HDAC6 degrader 14a

CAS#: N/A

Chemical Formula: C40H38N10O9

Exact Mass: 802.2823

Molecular Weight: 802.81

Elemental Analysis: C, 59.85; H, 4.77; N, 17.45; O, 17.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

HDAC6 degrader 14a; HDAC6-degrader-14a; HDAC6degrader14a; HDAC6degrader 14a; HDAC6degrader-14a; HDAC6 degrader14a; HDAC6-degrader14a

IUPAC/Chemical Name

4-((((2Z,3E)-1'-((1-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)methyl)-2'-oxo-[2,3'-biindolinylidene]-3-ylidene)amino)oxy)-N-hydroxybutanamide

InChi Key

DLBCMVGHLAVPJQ-ZQEKUULESA-N

InChi Code

InChI=1S/C40H38N10O9/c51-31-15-14-30(37(53)43-31)50-38(54)26-9-5-11-28(33(26)40(50)56)41-16-19-58-20-17-48-21-23(44-47-48)22-49-29-12-4-2-8-25(29)34(39(49)55)36-35(24-7-1-3-10-27(24)42-36)46-59-18-6-13-32(52)45-57/h1-5,7-12,21,30,41-42,57H,6,13-20,22H2,(H,45,52)(H,43,51,53)/b36-34-,46-35+

SMILES Code

O=C(CCCO/N=C1/C(NC2=C1C=CC=C2)=C3C(C=CC=C4)=C4N(CC5=CN(CCOCCNC6=CC=CC(C(N7C8C(NC(CC8)=O)=O)=O)=C6C7=O)N=N5)C\3=O)NO

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 802.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Bieliauskas AV, Weerasinghe SV, Negmeldin AT, Pflum MK. Structural Requirements of Histone Deacetylase Inhibitors: SAHA Analogs Modified on the Hydroxamic Acid. Arch Pharm (Weinheim). 2016 May;349(5):373-82. doi: 10.1002/ardp.201500472. Epub 2016 Apr 9. PMID: 27062198; PMCID: PMC6927578.