CP-628006 is a CFTR potentiator which restores ATP-dependent channel gating to the cystic fibrosis mutant G551D-CFTR. CP-628006 has distinct effects compared to ivacaftor, suggesting a different mechanism of CFTR potentiation. The emergence of CFTR potentiators with diverse modes of action makes therapy with combinations of potentiators a possibility.
MedKoo Cat#: 208027
Name: CP-628006
CAS#: 305822-08-6
Chemical Formula: C33H37F3N2O
Exact Mass: 534.2858
Molecular Weight: 534.67
Elemental Analysis: C, 74.13; H, 6.98; F, 10.66; N, 5.24; O, 2.99
The following data is based on the product molecular weight 534.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
