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MedKoo Cat#: 524855 | Name: CP-601927

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CP-601927 is a nicotinic acetylcholine receptor (nAChR) agonist. It is CNS-penetrant, high affinity, and selective (> 39fold-affinity).

Chemical Structure

CP-601927
CP-601927
CAS#357425-02-6, (free base)

Theoretical Analysis

MedKoo Cat#: 524855

Name: CP-601927

CAS#: 357425-02-6, (free base)

Chemical Formula: C12H12F3N

Exact Mass: 227.0922

Molecular Weight: 227.23

Elemental Analysis: C, 63.43; H, 5.32; F, 25.08; N, 6.16

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
357425-02-6 (free base) 328055-85-2 (racemic) 357425-68-4 (SR-isomer) 230615-01-7 (HCl)
Synonym
CP-601927; CP 601927; CP601927; CP-601,927; UNII-VI5LR1EU47.
IUPAC/Chemical Name
(1R,5S)-7-(trifluoromethyl)-2,3,4,5-tetrahydro-1H-1,5-methanobenzo[d]azepine
InChi Key
RNOBTWYQAWEZHH-JGVFFNPUSA-N
InChi Code
InChI=1S/C12H12F3N/c13-12(14,15)9-1-2-10-7-3-8(6-16-5-7)11(10)4-9/h1-2,4,7-8,16H,3,5-6H2/t7-,8+/m0/s1
SMILES Code
FC(C1=CC=C2[C@](C3)([H])CNC[C@]3([H])C2=C1)(F)F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 227.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Weber ML, Hofland CM, Shaffer CL, Flik G, Cremers T, Hurst RS, Rollema H. Therapeutic doses of antidepressants are projected not to inhibit human α4β2 nicotinic acetylcholine receptors. Neuropharmacology. 2013 Sep;72:88-95. doi: 10.1016/j.neuropharm.2013.04.027. Epub 2013 Apr 30. PubMed PMID: 23639435. 2: Campion SN, Hurtt ME, Chatman LA, Cappon GD. Toxicity study in juvenile rats with the α4β2 nicotinic acetylcholine receptor partial agonist CP-601,927. Birth Defects Res B Dev Reprod Toxicol. 2011 Aug;92(4):323-32. doi: 10.1002/bdrb.20298. Epub 2011 May 18. PubMed PMID: 21594972.

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