CG-12 | CAS# | Glucose uptake inhibitor

MedKoo Cat#: 208015 | Name: CG-12

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Inhibitor of glucose uptake, suppressing AR expression and increasing in the expression level of the E3 ligase β-transducin repeat-containing protein (β-TrCP)

Chemical Structure

CG-12

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 208015

Name: CG-12

CAS#: N/A

Chemical Formula: C19H20F3NO3S

Exact Mass: 399.1116

Molecular Weight: 399.43

Elemental Analysis: C, 57.13; H, 5.05; F, 14.27; N, 3.51; O, 12.02; S, 8.03

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

CG-12; CG 12; CG12

IUPAC/Chemical Name

(Z)-5-(4-hydroxy-3-(trifluoromethyl)benzylidene)-3-((1-methylcyclohexyl)methyl)thiazolidine-2,4-dione

InChi Key

MADFJWDIMPOGOZ-GDNBJRDFSA-N

InChi Code

InChI=1S/C19H20F3NO3S/c1-18(7-3-2-4-8-18)11-23-16(25)15(27-17(23)26)10-12-5-6-14(24)13(9-12)19(20,21)22/h5-6,9-10,24H,2-4,7-8,11H2,1H3/b15-10-

SMILES Code

FC(F)(F)C1=C(O)C=CC(/C=C(C(N2CC3(CCCCC3)C)=O)\SC2=O)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 399.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Wei S, Chu PC, Chuang HC, Hung WC, Kulp SK, Chen CS. Targeting the oncogenic E3 ligase Skp2 in prostate and breast cancer cells with a novel energy restriction-mimetic agent. PLoS One. 2012;7(10):e47298. doi: 10.1371/journal.pone.0047298. Epub 2012 Oct 12. PMID: 23071779; PMCID: PMC3470570. 2. Lin HY, Kuo YC, Weng YI, Lai IL, Huang TH, Lin SP, Niu DM, Chen CS. Activation of silenced tumor suppressor genes in prostate cancer cells by a novel energy restriction-mimetic agent. Prostate. 2012 Dec 1;72(16):1767-78. doi: 10.1002/pros.22530. Epub 2012 Apr 26. PMID: 22539223; PMCID: PMC3867924. 3. Chen CH, Huang PH, Chu PC, Chen MC, Chou CC, Wang D, Kulp SK, Teng CM, Wang Q, Chen CS. Energy restriction-mimetic agents induce apoptosis in prostate cancer cells in part through epigenetic activation of KLF6 tumor suppressor gene expression. J Biol Chem. 2011 Mar 25;286(12):9968-76. doi: 10.1074/jbc.M110.203240. Epub 2011 Jan 31. PMID: 21282102; PMCID: PMC3060551. 4. Colombatti M, Bisconti M, Lorenzi P, Stevanoni G, Dipasquale B, Gerosa M, Tridente G. Human glioma cell lines: tumour associated antigens distribution and sensitivity to antibody-toxin or ligand-toxin conjugates. A preliminary report. Acta Neurochir Suppl (Wien). 1988;43:121-5. doi: 10.1007/978-3-7091-8978-8_26. PMID: 3264995.