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MedKoo Cat#: 561605 | Name: Piretanide
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Piretanide is a time- and voltage-dependent blocker of CFTR Cl(-) currents. It also acts as a loop diuretic. Piretanide has been studied for its potential inhibitory effects on TPMT activity.

Chemical Structure

Piretanide
Piretanide
CAS#55837-27-9

Theoretical Analysis

MedKoo Cat#: 561605

Name: Piretanide

CAS#: 55837-27-9

Chemical Formula: C17H18N2O5S

Exact Mass: 362.0936

Molecular Weight: 362.40

Elemental Analysis: C, 56.34; H, 5.01; N, 7.73; O, 22.07; S, 8.85

Price and Availability

Size Price Availability Quantity
5mg USD 450.00 2 Weeks
10mg USD 650.00 2 Weeks
25mg USD 1,350.00 2 Weeks
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Related CAS #
No Data
Synonym
Piretanide; Tauliz; Arelix; Eurelix;
IUPAC/Chemical Name
4-Phenoxy-3-pyrrolidin-1-yl-5-sulfamoylbenzoic acid
InChi Key
UJEWTUDSLQGTOA-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H18N2O5S/c18-25(22,23)15-11-12(17(20)21)10-14(19-8-4-5-9-19)16(15)24-13-6-2-1-3-7-13/h1-3,6-7,10-11H,4-5,8-9H2,(H,20,21)(H2,18,22,23)
SMILES Code
O=C(O)C1=CC(S(=O)(N)=O)=C(OC2=CC=CC=C2)C(N3CCCC3)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Piretanide is a time- and voltage-dependent blocker of CFTR Cl(-) currents.
In vitro activity:
TBD
In vivo activity:
TBD
Solvent mg/mL mM comments
Solubility
DMSO 250.0 689.85
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 362.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
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Peripheral and central antinociceptive action of Na+-K+-2Cl- cotransporter blockers on formalin-induced nociception in rats. Pain. 2005 Mar;114(1-2):231-8. doi: 10.1016/j.pain.2004.12.023. Epub 2005 Jan 26. PMID: 15733649. 15: Buffin-Meyer B, Younes-Ibrahim M, El Mernissi G, Cheval L, Marsy S, Grima M, Girolami JP, Doucet A. Differential regulation of collecting duct Na+, K+-ATPase and K+ excretion by furosemide and piretanide: role of bradykinin. J Am Soc Nephrol. 2004 Apr;15(4):876-84. doi: 10.1097/01.asn.0000117773.22969.b3. PMID: 15034089. 16: Ruiz-Angel MJ, Torres-Lapasió JR, García-Alvarez-Coque MC. Effects of pH and the presence of micelles on the resolution of diuretics by reversed-phase liquid chromatography. J Chromatogr A. 2004 Jan 2;1022(1-2):51-65. doi: 10.1016/j.chroma.2003.09.061. PMID: 14753771. 17: Prestel R, Storck M, Hammer C, Abendroth D. 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