DPPS | anionic diacyl phospholipid | CAS#145849-32-7

MedKoo Cat#: 471172 | Name: DPPS

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DPPS is a form of phosphatidylserine (PS), an anionic phospholipid.

Chemical Structure

DPPS

CAS#145849-32-7

Theoretical Analysis

MedKoo Cat#: 471172

Name: DPPS

CAS#: 145849-32-7

Chemical Formula: C38H73NNaO10P

Exact Mass: 0.0000

Molecular Weight: 757.96

Elemental Analysis: C, 60.22; H, 9.71; N, 1.85; Na, 3.03; O, 21.11; P, 4.09

Price and Availability

Size	Price	Availability
25mg	USD 150.00	Ready to ship
50mg	USD 250.00	Ready to ship
100mg	USD 450.00	Ready to ship
250mg	USD 955.00	Ready to ship
500mg	USD 1,650.00	Ready to ship
1g	USD 2,805.00	Ready to ship

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Related CAS #

No Data

Synonym

DPPS; 1,2-DPPS; PS 16:0/16:0; 1,2-Dipalmitoyl-sn-glycero-3-phospho-L-serine

IUPAC/Chemical Name

(2S,8R)-2-amino-5-hydroxy-11-oxo-8-[(1-oxohexadecyl)oxy]-4,6,10-trioxa-5-phosphahexacosanoic acid, 5-oxide, monosodium salt

InChi Key

GTLXLANTBWYXGW-CEGNZRHUSA-M

InChi Code

InChI=1S/C38H74NO10P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-36(40)46-31-34(32-47-50(44,45)48-33-35(39)38(42)43)49-37(41)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h34-35H,3-33,39H2,1-2H3,(H,42,43)(H,44,45);/q;+1/p-1/t34-,35+;/m1./s1

SMILES Code

O=C(OC[C@H](COP(OC[C@@H](C([O-])=O)[NH3+])([O-])=O)OC(CCCCCCCCCCCCCCC)=O)CCCCCCCCCCCCCCC.[Na+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in chloroform

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in chloroform

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Certificate of Analysis

View CoA: current batch, Lot#A23T04K28

QC Data

View QC data: current batch, Lot#A23T04K28

Safety Data Sheet (SDS)

View Safety Data Sheet (SDS)

Instruction

View handling instruction

Biological target:

Phosphatidylserine (PS) is an anionic phospholipid that is normally restricted to the inner leaflet of the plasma membrane bilayer of cells, appearing on the outer leaflet early in apoptosis and thus available for recognition by phagocytes. DPPS is a form of PS that contains the abundant long-chain (16:0) palmitic acid inserted at the sn-1 and sn-2 positions. It is commonly used in the generation of liposomes and other types of artificial membranes.

In vitro activity:

There is a critical size after which DPPS single shell vesicles are no longer stable. This study was able to infer a lower bound for the area dilation modulus for DPPS (252 pN/nm) and demonstrate a substantial free energy increase associated with vesicle rupture. Reference: Langmuir. 2012 Aug 14;28(32):11874-80. https://pubmed.ncbi.nlm.nih.gov/22799521/

In vivo activity:

A rat model of laser-induced choroidal neovascularization showed that annexin-DPPS-phytantriol (ANX-PS-Phy) cubosomes specifically targeted apoptotic cells in vivo. This study proposes that ANX-PS-Phy cubosomes are a potential candidate for ocular drug delivery for eye diseases. Reference: J Mater Chem B. 2018 Dec 14;6(46):7652-7661. https://pubmed.ncbi.nlm.nih.gov/32254887/

	Solvent	mg/mL	mM
Solubility
	Chloroform	0.5	0.66

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 757.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Brown KL, Conboy JC. Lipid flip-flop in binary membranes composed of phosphatidylserine and phosphatidylcholine. J Phys Chem B. 2013 Dec 5;117(48):15041-50. doi: 10.1021/jp409672q. Epub 2013 Nov 22. PMID: 24200035. 2. Marr JM, Li F, Petlick AR, Schafer R, Hwang CT, Chabot A, Ruggiero ST, Tanner CE, Schultz ZD. The role of lateral tension in calcium-induced DPPS vesicle rupture. Langmuir. 2012 Aug 14;28(32):11874-80. doi: 10.1021/la301976s. Epub 2012 Jul 30. PMID: 22799521; PMCID: PMC3422639. 3. Ding Y , Chow SH , Liu GS , Wang B , Lin TW , Hsu HY , Duff AP , Le Brun AP , Shen HH . Annexin V-containing cubosomes for targeted early detection of apoptosis in degenerative retinal tissue. J Mater Chem B. 2018 Dec 14;6(46):7652-7661. doi: 10.1039/c8tb02465k. Epub 2018 Nov 5. PMID: 32254887.

In vitro protocol:

In vivo protocol:

1. Ding Y , Chow SH , Liu GS , Wang B , Lin TW , Hsu HY , Duff AP , Le Brun AP , Shen HH . Annexin V-containing cubosomes for targeted early detection of apoptosis in degenerative retinal tissue. J Mater Chem B. 2018 Dec 14;6(46):7652-7661. doi: 10.1039/c8tb02465k. Epub 2018 Nov 5. PMID: 32254887.

1: Veronezi G, Rosa ME, Rodrigues JC, Caseli L. Lipid saturation modulates the interaction of anastrozole with biointerfaces. Arch Biochem Biophys. 2025 Apr 3;769:110408. doi: 10.1016/j.abb.2025.110408. Epub ahead of print. PMID: 40187716. 2: Sewald L, Tabak WWA, Fehr L, Zolg S, Najdzion M, Verhoef CJA, Podlesainski D, Geiss-Friedlander R, Lammens A, Kaschani F, Hellerschmied D, Huber R, Kaiser M. Sulphostin-inspired N-phosphonopiperidones as selective covalent DPP8 and DPP9 inhibitors. Nat Commun. 2025 Apr 3;16(1):3208. doi: 10.1038/s41467-025-58493-z. PMID: 40180908; PMCID: PMC11968843. 3: Qin L, Zhai Q, Cui Z, Li H, Guan J, Zhang Z, Xu E, Zhang X, Mao S. Elucidating structure of endogenous phospholipids on in vivo absorption of octreotide following lung administration. Eur J Pharm Biopharm. 2025 Mar 31:114706. doi: 10.1016/j.ejpb.2025.114706. Epub ahead of print. PMID: 40174681. 4: Dos Santos AGA, Cassas F, Dos Santos KF, de Medeiros LS, Veiga TAM, Caseli L. Interaction of Myrsinoic acid a with biomembrane models: Differential effects on DPPC and DPPS properties revealed by surface rheology and vibrational spectroscopy. Biophys Chem. 2025 Mar 28;322:107439. doi: 10.1016/j.bpc.2025.107439. Epub ahead of print. PMID: 40168714. 5: Haseldine C, Pallin JA, Kearney PM, Mc Hugh SM, Riordan F, Cotterill S, O'Donoghue G. Healthcare workers' perspectives on barriers and facilitators to referral to type 2 diabetes prevention programmes: a systematic review. BMJ Open. 2025 Mar 7;15(3):e090105. doi: 10.1136/bmjopen-2024-090105. PMID: 40054870; PMCID: PMC11891527. 6: Chirico V, Silipigni L, Tripodi F, Conti G, Rulli I, Granata F, Cinquegrani A, Santoro D, Gitto E, Chimenz R. Management dilemma of anti-GBM disease and p-ANCA-associated vasculitis with necrotizing skin lesions in a pediatric patient. Pediatr Nephrol. 2025 Mar 3. doi: 10.1007/s00467-025-06721-5. Epub ahead of print. PMID: 40029412. 7: Miyata K, Kobayakawa S. 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PMID: 39918301. 10: Shen Y, Wang L, Chen N, Wang L, Wang Y, Pan Q, Li L, Ding X, Gu Z, Li F, Ju W, Li M, Chen H, Yang G, Gu K, Liu H, Chen M. Ablation of Premature Ventricular Contractions With Prepotentials Mapped Inside Coronary Cusps: When to Go Infra- Valvular? J Cardiovasc Electrophysiol. 2025 Apr;36(4):783-793. doi: 10.1111/jce.16587. Epub 2025 Jan 29. PMID: 39887858. 11: Stephenson-Hunter C, Gonzalez CJ, Franco S, Hashmi M, Tisor O, Gonzalez CM. Primary care providers' perspectives on referrals to the Diabetes Prevention Programme: a qualitative comparative study across varied referral patterns. BMJ Nutr Prev Health. 2024 Aug 3;7(2):e000932. doi: 10.1136/bmjnph-2024-000932. PMID: 39882293; PMCID: PMC11773654. 12: Meng Z, Kotani Y, Wang P, Zhao H, Li H. Polarization-independent dual-peak filter based on a cylindrically symmetric helical small-period fiber grating. Opt Express. 2025 Jan 27;33(2):3281-3289. doi: 10.1364/OE.550786. PMID: 39876455. 13: Vanella G, Leone R, Frigo F, Rossi G, Zaccari P, Palumbo D, Guazzarotti G, Aleotti F, Pecorelli N, Preatoni P, Aldrighetti L, Falconi M, Capurso G, De Cobelli F, Arcidiacono PG. Predicting the need for step-up after EUS-guided drainage of peripancreatic fluid collections, including Quadrant Necrosis Infection score validation: a prospective cohort study. Gastrointest Endosc. 2025 Jan 20:S0016-5107(25)00044-6. doi: 10.1016/j.gie.2025.01.019. Epub ahead of print. PMID: 39842518. 14: Freeman MT, Parvaresh-Rizi A, Meenach SA. Enhanced Macrophage Uptake of Spray-Dried Phosphatidylserine-Loaded Microparticles for Pulmonary Drug Delivery Applications. J Drug Deliv Sci Technol. 2025 Feb;104:106535. doi: 10.1016/j.jddst.2024.106535. Epub 2024 Dec 13. PMID: 39830679; PMCID: PMC11737435. 15: Liu B, Wei R, Wang Y, Cheng Z, Jiang L, Pu X, Zhang Y, Wang Y, Kang Q. Integrative Proteomics and Phosphoproteomics Profiling of Symptomatic Accessory Navicular Bone Based on Tandem Mass Tag Technology. Int J Gen Med. 2024 Dec 14;17:6207-6218. doi: 10.2147/IJGM.S484303. PMID: 39698044; PMCID: PMC11653880. 16: Al-Jaaidi A, Toldo JM, Barbatti M. Ultrafast Dynamics of Diketopyrrolopyrrole Dimers. J Comput Chem. 2025 Jan 5;46(1):e27547. doi: 10.1002/jcc.27547. PMID: 39673543; PMCID: PMC11645985. 17: Wrobel EC, de Lara LS, de Fátima Â, Oliveira ON Jr. Nanoarchitectonics and Simulation on the Molecular-Level Interactions between p-Sulfonic Acid Calix[4]arene and Langmuir Monolayers Representing Healthy and Cancerous Cell Membranes. Langmuir. 2024 Dec 24;40(51):27010-27027. doi: 10.1021/acs.langmuir.4c03948. Epub 2024 Dec 11. PMID: 39663612; PMCID: PMC11673576. 18: Cheng Y, Ren Y, Zhang W, Lu J, Xie F, Fang YD, Fan X, He W, Wang W. Regionalization of intestinal microbiota and metabolites in the small intestine of the Bactrian camel. Front Immunol. 2024 Nov 26;15:1464664. doi: 10.3389/fimmu.2024.1464664. PMID: 39660142; PMCID: PMC11628504. 19: Johnston CE, MacPherson MM, Jung ME. Are Diabetes Prevention Programs Reaching Those Most at Risk? A Scoping Review. Can J Diabetes. 2024 Nov 29:S1499-2671(24)00402-7. doi: 10.1016/j.jcjd.2024.11.006. Epub ahead of print. PMID: 39617265. 20: Kluszczyk P, Jabłońska B, Serafin M, Tobiasz A, Kowalczyk T, Maślanka S, Chapuła M, Wosiewicz P, Mrowiec S. What We Know So Far About ECG for Pancreatic Pseudocysts. Life (Basel). 2024 Nov 4;14(11):1419. doi: 10.3390/life14111419. PMID: 39598217; PMCID: PMC11595481.