MedKoo Cat#: 578118 | Name: NH-3
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

NH-3 is an orally active, reversible THR antagonist with an IC50 of 55 nM. NH-3 inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment. NH-3 is a derivative of the thyromi-metic GC-1,

Chemical Structure

NH-3
CAS#447415-26-1

Theoretical Analysis

MedKoo Cat#: 578118

Name: NH-3

CAS#: 447415-26-1

Chemical Formula: C28H27NO6

Exact Mass: 473.1838

Molecular Weight: 473.52

Elemental Analysis: C, 71.02; H, 5.75; N, 2.96; O, 20.27

Price and Availability

Size Price Availability Quantity
5mg USD 1,050.00 2 Weeks
10mg USD 1,750.00 2 Weeks
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Related CAS #
No Data
Synonym
NH-3; NH 3; NH3
IUPAC/Chemical Name
Acetic acid, (4-((4-hydroxy-3-(1-methylethyl)-5-((4-nitrophenyl)ethynyl)phenyl)methyl)-3,5-dimethylphenoxy)-
InChi Key
IXMROOKFPWGDGF-UHFFFAOYSA-N
InChi Code
1S/C28H27NO6/c1-17(2)25-14-21(15-26-18(3)11-24(12-19(26)4)35-16-27(30)31)13-22(28(25)32)8-5-20-6-9-23(10-7-20)29(33)34/h6-7,9-14,17,32H,15-16H2,1-4H3,(H,30,31)
SMILES Code
CC(C)c1cc(Cc2c(C)cc(OCC(=O)O)cc2C)cc(C#Cc3ccc(cc3)[N+](=O)[O-])c1O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Thyroid hormones (THs) are essential for normal vertebrate development and diverse environmental chemicals are hypothesized to cause developmental toxicity by disrupting TH-mediated signaling. The larval zebrafish (Danio rerio) is an emerging in vivo model of developmental TH disruption; however, the effects of TR antagonism have not yet been studied in zebrafish. NH3, generally considered a potent and specific thyroid hormone receptor (TR) antagonist, has been used in rodents and Xenopus laevis to characterize phenotypes of TR antagonism.

Preparing Stock Solutions

The following data is based on the product molecular weight 473.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Singh L, Pressly B, Mengeling BJ, Fettinger JC, Furlow JD, Lein PJ, Wulff H, Singh V. Chasing the Elusive Benzofuran Impurity of the THR Antagonist NH-3: Synthesis, Isotope Labeling, and Biological Activity. J Org Chem. 2016 Mar 4;81(5):1870-6. doi: 10.1021/acs.joc.5b02665. Epub 2016 Feb 18. PMID: 26849160. 2. Schreiber T, Gassmann K, Götz C, Hübenthal U, Moors M, Krause G, Merk HF, Nguyen NH, Scanlan TS, Abel J, Rose CR, Fritsche E. Polybrominated diphenyl ethers induce developmental neurotoxicity in a human in vitro model: evidence for endocrine disruption. Environ Health Perspect. 2010 Apr;118(4):572-8. doi: 10.1289/ehp.0901435. PMID: 20368126; PMCID: PMC2854737. 3. Walter KM, Singh L, Singh V, Lein PJ. Investigation of NH3 as a selective thyroid hormone receptor modulator in larval zebrafish (Danio rerio). Neurotoxicology. 2021 May;84:96-104. doi: 10.1016/j.neuro.2021.03.003. Epub 2021 Mar 18. PMID: 33745965; PMCID: PMC8119357.