MedKoo Cat#: 578113 | Name: Nedometinib
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Nedometinib, also known as NFX-179 is a tyrosine kinase inhibitor and antineoplastic.

Chemical Structure

Nedometinib
Nedometinib
CAS#2252314-46-6

Theoretical Analysis

MedKoo Cat#: 578113

Name: Nedometinib

CAS#: 2252314-46-6

Chemical Formula: C17H16FIN4O3

Exact Mass: 470.0251

Molecular Weight: 470.24

Elemental Analysis: C, 43.42; H, 3.43; F, 4.04; I, 26.99; N, 11.91; O, 10.21

Price and Availability

Size Price Availability Quantity
25mg USD 450.00 2 Weeks
50mg USD 750.00 2 Weeks
100mg USD 1,250.00 2 Weeks
200mg USD 1,950.00 2 Weeks
500mg USD 3,850.00 2 Weeks
1g USD 5,450.00 2 Weeks
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Related CAS #
Synonym
NFX-179; NFX 179; NFX179, nedometinib
IUPAC/Chemical Name
2-((2-Fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)-1-methyl-1H-pyrrolo(2,3-b)pyridine-3-carboxamide
InChi Key
SENAOZROGSYRTD-UHFFFAOYSA-N
InChi Code
1S/C17H16FIN4O3/c1-23-15-11(3-2-6-20-15)14(17(25)22-26-8-7-24)16(23)21-13-5-4-10(19)9-12(13)18/h2-6,9,21,24H,7-8H2,1H3,(H,22,25)
SMILES Code
Cn1c(Nc2ccc(I)cc2F)c(C(=O)NOCCO)c3cccnc13
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 470.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
[1]. Kincaid, et al. Preparation of pyrrolopyridine-aniline compounds for treatment of dermal disorders. World Intellectual Property Organization, WO2018213810 A1. 2018-11-22. https://www.freepatentsonline.com/WO2018213810A1.html#google_vignette