MedKoo Cat#: 578099 | Name: Potassium nervonate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Potassium nervonate is a very long chain fatty acid produced by elongation of oleic acid and derived from erucic acid. It is enriched in nervous tissue and is particularly abundant in sphingolipids, such as sphingomyelin in the myelin sheath of nerve fibers. Nervonic acid is poorly produced in demyelinating disorders, including multiple sclerosis and adrenoleukodystrophy, suggesting that dietary supplementation may be beneficial. Nervonic acid also binds and inhibits DNA polymerase β and HIV-1 reverse transcriptase.

Chemical Structure

Potassium nervonate
Potassium nervonate
CAS#18175-48-9

Theoretical Analysis

MedKoo Cat#: 578099

Name: Potassium nervonate

CAS#: 18175-48-9

Chemical Formula: C24H45KO2

Exact Mass: 404.3057

Molecular Weight: 404.72

Elemental Analysis: C, 71.23; H, 11.21; K, 9.66; O, 7.91

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Nervonic acid potassium salt; Potassium nervonate
IUPAC/Chemical Name
15-Tetracosenoic acid, potassium salt, (Z)-
InChi Key
CPUISZFKMKNUMZ-KVVVOXFISA-M
InChi Code
InChI=1S/C24H46O2.K/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26;/h9-10H,2-8,11-23H2,1H3,(H,25,26);/q;+1/p-1/b10-9-;
SMILES Code
[K+].CCCCCCCC\C=C/CCCCCCCCCCCCCC(=O)[O-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 404.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Taylor, D.C., Francis, T., Guo, Y., et al. Molecular cloning and characterization of a KCS gene from Cardamine graeca and its heterologous expression in Brassica oilseeds to engineer high nervonic acid oils for potential medical and industrial use. Plant Biotechnol.J. 7, 925-938 (2009). 2. Hirvisalo, E.L., and Renkonen, O. Composition of human serum sphingomyelins. J. Lipid Res. 11, 54-59 (1970). 3. Sargent, J.R., Coupland, K., and Wilson, R. Nervonic acid and demyelinating disease. Med. Hypotheses 42, 237-242 (1994). 4. Baumann, N.A., Jacque, C.M., Pollet, S.A., et al. Fatty acid and lipid composition of the brain of a myelin deficient mutant, the "quaking" mouse. Eur. J. Biochem. 4, 340-344 (1968). 5. Cook, C., Barnett, J., Coupland, K., et al. Effects of feeding Lunaria oil rich in nervonic and erucic acids on the fatty acid compositions of sphingomyelins from erythrocytes, liver, and brain of the quaking mouse mutant. Lipids 33(10), 993-1000 (1998). 6. Kasai, N., Mizushina, Y., Sugawara, F., et al. Three-dimensional structural model analysis of the binding site of an inhibitor, nervonic acid, of both DNA polymerase β and HIV-1 reverse transcriptase. J. Biochem. 132, 819-828 (2002).