MD13, also known as MIF degrader MD13, is a potent MIF (macrophage migration inhibitory factor) Degrader (PROTAC®) (DC50 < 100 nM; Dmax = 92% after 6 h). MD13 comprises the cereblon ligand Pomalidomide joined by a linker to a MIF inhibitor. MD13 reduces MIF levels, arrests cells at the G2/M phase and inhibits proliferation of A549 lung carcinoma cells. Growth of A549 cell 3D spheroids is also inhibited by MDF13.
MedKoo Cat#: 466229
Name: MD13
CAS#: 2758431-97-7
Chemical Formula: C35H35N5O8
Exact Mass: 653.2486
Molecular Weight: 653.69
Elemental Analysis: C, 64.31; H, 5.40; N, 10.71; O, 19.58
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 65.4 | 100.00 |
The following data is based on the product molecular weight 653.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
