Substance P (1-4) | CAS#69355-89-1 | N-terminal tetrapeptide

MedKoo Cat#: 597816 | Name: Substance P (1-4)

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Substance P (1-4) is the N-terminal tetrapeptide fragment of substance P.

Chemical Structure

Substance P (1-4)

CAS#69355-89-1

Theoretical Analysis

MedKoo Cat#: 597816

Name: Substance P (1-4)

CAS#: 69355-89-1

Chemical Formula: C22H41N9O4

Exact Mass: 495.3282

Molecular Weight: 495.62

Elemental Analysis: C, 53.31; H, 8.34; N, 25.43; O, 12.91

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Substance P (1-4); SP(1-4);

IUPAC/Chemical Name

(S)-1-(L-arginyl)-N-((S)-6-amino-1-((S)-2-carbamoylpyrrolidin-1-yl)-1-oxohexan-2-yl)pyrrolidine-2-carboxamide

InChi Key

GTDHNQNCXUYISG-QAETUUGQSA-N

InChi Code

InChI=1S/C22H41N9O4/c23-10-2-1-7-15(21(35)30-12-4-8-16(30)18(25)32)29-19(33)17-9-5-13-31(17)20(34)14(24)6-3-11-28-22(26)27/h14-17H,1-13,23-24H2,(H2,25,32)(H,29,33)(H4,26,27,28)/t14-,15-,16-,17-/m0/s1

SMILES Code

O=C(N)[C@H]1N(C([C@H](CCCCN)NC([C@H]2N(C([C@H](CCCNC(N)=N)N)=O)CCC2)=O)=O)CCC1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 495.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Nieber K, Oehme P, Arefolov VA, Valdman AV. Effect of the N-terminal tetrapeptide of substance P SP (1-4) and tuftsin on the pre- and postsynaptic transmitter outflow in rat adrenal gland slices. Biomed Biochim Acta. 1988;47(7):663-6. PubMed PMID: 2462417. 2: Minenko A, Tjulkova E, Oehme P. Effects of substance P (SP) and the N-terminal SP-analogue SP (1-4) on inositol phospholipids in rat adrenal medulla slices. Biomed Biochim Acta. 1988;47(9):871-9. PubMed PMID: 2470365. 3: Nieber K, Oehme P. Effect of substance P (SP) and the N-terminal SP-analogue SP (1-4) on the pre- and postsynaptic transmitter release in rat adrenal gland slices. Biomed Biochim Acta. 1987;46(1):103-9. PubMed PMID: 2437900. 4: Le Gall C, Ianotto JC, Hardy E, Ugo V, Eveillard JR, Ngo-Sack F, Bourquard P, Morice P, Berthou C. Inhibitory effect of the substance P and its derivative on erythropoietin-independent growth of erythroid progenitors in polycythemia vera. Leuk Res. 2008 May;32(5):743-54. Epub 2007 Nov 5. PubMed PMID: 17980427. 5: Sakurada C, Watanabe C, Sakurada S, Tan-No K, Sakurada T. Major metabolites of substance P degraded by spinal synaptic membranes antagonize the behavioral response to substance P in rats. J Pharm Sci. 1999 Nov;88(11):1127-32. PubMed PMID: 10564060. 6: Oehme P, Hecht K, Jumatov J, Repke H, Hilse H, Cordova A. Prevention of stress-induced involution of the thymus in rats by substance P (SP1-11) and its N-terminal fragment SP1-4. Pharmazie. 1987 Jan;42(1):34-6. PubMed PMID: 2437598. 7: Hafström I, Gyllenhammar H, Palmblad J, Ringertz B. Substance P activates and modulates neutrophil oxidative metabolism and aggregation. J Rheumatol. 1989 Aug;16(8):1033-7. PubMed PMID: 2479743. 8: Gorizontova MP, Odariuk Iu, Binert M. [Effect of the N-terminal fragment of substance P on the microcirculatory system]. Biull Eksp Biol Med. 1988 Apr;105(4):403-5. Russian. PubMed PMID: 2451944. 9: Mårtensson B, Nyberg S, Toresson G, Brodin E, Bertilsson L. Fluoxetine treatment of depression. Clinical effects, drug concentrations and monoamine metabolites and N-terminally extended substance P in cerebrospinal fluid. Acta Psychiatr Scand. 1989 Jun;79(6):586-96. PubMed PMID: 2475012. 10: Semion IZ, Nawrocka E, Słoń J, Tartar A, Obuchowicz E, Gołba K, Herman ZS. Antinociceptive action of the SP1-4 tetrapeptide and of some tuftsin analogs. Pol J Pharmacol Pharm. 1990 Jul-Aug;42(4):393-401. PubMed PMID: 1711198. 11: Cascieri MA, Huang RR, Fong TM, Cheung AH, Sadowski S, Ber E, Strader CD. Determination of the amino acid residues in substance P conferring selectivity and specificity for the rat neurokinin receptors. Mol Pharmacol. 1992 Jun;41(6):1096-9. PubMed PMID: 1377326. 12: Gorizontova MP. [Effect of substance P and its N-terminal fragment on the components of the normal microcirculatory system and under stress]. Fiziol Zh SSSR Im I M Sechenova. 1989 May;75(5):709-14. Russian. PubMed PMID: 2475368. 13: Arefolov VA, Malikova LA, Val'dman AV, Nieber K, Oehme P. [Effect of the N-terminal fragment of substance P1-4 on the somatic manifestations of the stress reaction and on the catecholamine content of the adrenals in rats]. Biull Eksp Biol Med. 1989 Feb;107(2):201-4. Russian. PubMed PMID: 2466499. 14: Otter A, Kotovych G, Stewart JM. One- and two-dimensional 1H NMR study of the substance P fragment ARG-PRO-Lys-Pro. J Biomol Struct Dyn. 1986 Jun;3(6):1121-31. PubMed PMID: 2482748. 15: Yench KD, Oehme P, Lindner G, Pegelov I, Neibert K. [Biological action of the N-terminal fragments of substance P]. Patol Fiziol Eksp Ter. 1984 May-Jun;(3):75-7. Russian. PubMed PMID: 6206460. 16: Spevak SE, Shekhter AB, Hilse H, Oehme P, Solov'eva AI. [Characteristics of the course of the wound process in spontaneously hypertensive rats and the effect of morphine, substance P and its fragment SP1-4]. Biull Eksp Biol Med. 1989 Jun;107(6):739-43. Russian. PubMed PMID: 2477078. 17: Veronesi B, Carter JD, Devlin RB, Simon SA, Oortgiesen M. Neuropeptides and capsaicin stimulate the release of inflammatory cytokines in a human bronchial epithelial cell line. Neuropeptides. 1999 Dec;33(6):447-56. PubMed PMID: 10657523.