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MedKoo Cat#: 466220 | Name: TDI-6118

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TDI-6118 is an EHZ2 inhibitor (IC50 = 14 nM).

Chemical Structure

TDI-6118
TDI-6118
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 466220

Name: TDI-6118

CAS#: unknown

Chemical Formula: C23H23Cl2N3O3

Exact Mass: 459.1116

Molecular Weight: 460.36

Elemental Analysis: C, 60.01; H, 5.04; Cl, 15.40; N, 9.13; O, 10.43

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
TDI-6118; TDI6118; TDI 6118;
IUPAC/Chemical Name
5,8-dichloro-7-(3,5-dimethylisoxazol-4-yl)-2-((1,4,6-trimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one
InChi Key
GWDVHMHVEQPHSR-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H23Cl2N3O3/c1-11-8-12(2)27(5)22(29)17(11)10-28-7-6-15-18(24)9-16(21(25)20(15)23(28)30)19-13(3)26-31-14(19)4/h8-9H,6-7,10H2,1-5H3
SMILES Code
CN1C(C)=CC(C)=C(CN2C(C3=C(Cl)C(C4=C(C)ON=C4C)=CC(Cl)=C3CC2)=O)C1=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 460.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liang R, Tomita D, Sasaki Y, Ginn J, Michino M, Huggins DJ, Baxt L, Kargman S, Shahid M, Aso K, Duggan M, Stamford AW, DeStanchina E, Liverton N, Meinke PT, Foley MA, Phillips RE. A Chemical Strategy toward Novel Brain-Penetrant EZH2 Inhibitors. ACS Med Chem Lett. 2022 Feb 10;13(3):377-387. doi: 10.1021/acsmedchemlett.1c00448. PMID: 35300079; PMCID: PMC8919293.

View History

SC-22716

SC-22716