YM-458 is a Dual EZH2/BRD4 Inhibitors to Target Solid Tumors. It has an IC50 (EZH2)=490 nM and IC50 (BRD4)= 34 nM. YM458 displays potent inhibitory activity against EZH2 and BRD4 and remarkable antiproliferative capacity against 11 solid cancer cell lines. Its in vivo therapeutic potential is validated in both lung cancer and pancreatic cancer xenograft tumor mice models, highlighting the potential of EZH2/BRD4 dual inhibitors to target a broad scope of EZH2 inhibitor-resistant solid tumors.
MedKoo Cat#: 466204
Name: YM-458
CAS#: unknown
Chemical Formula: C53H61ClN8O5S
Exact Mass: 956.4174
Molecular Weight: 957.63
Elemental Analysis: C, 66.47; H, 6.42; Cl, 3.70; N, 11.70; O, 8.35; S, 3.35
The following data is based on the product molecular weight 957.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
