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MedKoo Cat#: 578014 | Name: Sildenafil nitrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sildenafil nitrate is a selective inhibitor of PDE5 (type 5 cGMP phosphodiesterase) which catalyzes the hydrolysis of 3',5'-cyclic guanosine monophosphate (cGMP).

Chemical Structure

Sildenafil nitrate
CAS#252951-59-0 (nitrate)

Theoretical Analysis

MedKoo Cat#: 578014

Name: Sildenafil nitrate

CAS#: 252951-59-0 (nitrate)

Chemical Formula: C22H31N7O7S

Exact Mass: 537.2006

Molecular Weight: 537.59

Elemental Analysis: C, 49.15; H, 5.81; N, 18.24; O, 20.83; S, 5.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
139755-83-2 (free base) 171599-83-0 (citrate) 252951-59-0 (nitrate)
Synonym
NCX-911; NCX 911; NCX911; Sildenafil nitrate
IUPAC/Chemical Name
Piperazine, 1-((3-(4,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methyl-, mononitrate
InChi Key
RBQNFEVGNSBKSU-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H30N6O4S.HNO3/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28;2-1(3)4/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29);(H,2,3,4)
SMILES Code
CCCc1nn(C)c2C(=O)NC(=Nc12)c3cc(ccc3OCC)S(=O)(=O)N4CCN(C)CC4.O[N+](=O)[O-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 537.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Sildenafil Can Affect Innate and Adaptive Immune System in Both Experimental Animals and Patients. J Immunol Res. 2017;2017:4541958. doi: 10.1155/2017/4541958. Epub 2017 Feb 20. Review. PubMed PMID: 28316997; PubMed Central PMCID: PMC5337856. 12: Efremov EA, Kasatonova EV, Melnik YI, Simakov VV. [Contemporary aspects of using sildenafil]. Urologiia. 2016 Nov;(5):120-128. Review. Russian. PubMed PMID: 28248033. 13: Scaglione F, Donde S, Hassan TA, Jannini EA. Phosphodiesterase Type 5 Inhibitors for the Treatment of Erectile Dysfunction: Pharmacology and Clinical Impact of the Sildenafil Citrate Orodispersible Tablet Formulation. Clin Ther. 2017 Feb;39(2):370-377. doi: 10.1016/j.clinthera.2017.01.001. Epub 2017 Jan 28. Review. PubMed PMID: 28139291. 14: Dunn L, Greer R, Flenady V, Kumar S. Sildenafil in Pregnancy: A Systematic Review of Maternal Tolerance and Obstetric and Perinatal Outcomes. Fetal Diagn Ther. 2017;41(2):81-88. doi: 10.1159/000453062. Epub 2016 Dec 8. Review. PubMed PMID: 27926905. 15: Chen J, Gong X, Chen P, Luo K, Zhang X. Effect of L-arginine and sildenafil citrate on intrauterine growth restriction fetuses: a meta-analysis. BMC Pregnancy Childbirth. 2016 Aug 16;16:225. doi: 10.1186/s12884-016-1009-6. Review. PubMed PMID: 27528012; PubMed Central PMCID: PMC4986189. 16: Lu X, Han H, Xing N, Tian L. [Efficacy of sildenafil citrate in men with erectile dysfunction following bilateral nerve-sparing radical prostatectomy: systematic review and meta-analysis]. Zhonghua Yi Xue Za Zhi. 2015 Sep 22;95(36):2964-8. Review. Chinese. PubMed PMID: 26814076. 17: Dodgen AL, Hill KD. Safety and tolerability considerations in the use of sildenafil for children with pulmonary arterial hypertension. Drug Healthc Patient Saf. 2015 Dec 15;7:175-83. doi: 10.2147/DHPS.S65571. eCollection 2015. Review. PubMed PMID: 26719728; PubMed Central PMCID: PMC4687613. 18: Perez KM, Laughon M. Sildenafil in Term and Premature Infants: A Systematic Review. 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