INE963 is a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria. INE963 demonstrates potent cellular activity against Pf 3D7 (EC50 = 0.006 μM) and achieves "artemisinin-like" kill kinetics in vitro with a parasite clearance time of <24 h. A single dose of 30 mg/kg is fully curative in the Pf-humanized severe combined immunodeficient mouse model. INE963 also exhibits a high barrier to resistance in drug selection studies and a long half-life (T1/2) across species.
MedKoo Cat#: 556080
Name: INE963 HCl
CAS#: INE963 HCl
Chemical Formula: C19H28Cl2N6O2S
Exact Mass: 0.0000
Molecular Weight: 475.43
Elemental Analysis: C, 48.00; H, 5.94; Cl, 14.91; N, 17.68; O, 6.73; S, 6.74
The following data is based on the product molecular weight 475.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
