TRULI | CAS#1424635-83-5 | Lats1/Lats2 Inhibitor

MedKoo Cat#: 471152 | Name: TRULI

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TRULI (also known as LATS-IN-1) is a synthetic small-molecule inhibitor targeting the Large Tumor Suppressor kinases LATS1 and LATS2, with an IC₅₀ of approximately 0.2 nM. By inhibiting these kinases, TRULI suppresses YAP phosphorylation, leading to increased YAP activity and subsequent promotion of cell proliferation in various cell lines and tissues.

Chemical Structure

TRULI

CAS#1424635-83-5

Theoretical Analysis

MedKoo Cat#: 471152

Name: TRULI

CAS#: 1424635-83-5

Chemical Formula: C18H14N4OS

Exact Mass: 334.0890

Molecular Weight: 334.40

Elemental Analysis: C, 64.65; H, 4.22; N, 16.75; O, 4.78; S, 9.59

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 300.00	2 Weeks
50mg	USD 950.00	2 Weeks

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Related CAS #

No Data

Synonym

TRULI, Lats-IN-1, LATS Inhibitor 1

IUPAC/Chemical Name

(Z)-N-(3-benzylthiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide

InChi Key

VTXBMVZVPUSAJF-UZYVYHOESA-N

InChi Code

InChI=1S/C18H14N4OS/c23-17(15-11-20-16-14(15)7-4-8-19-16)21-18-22(9-10-24-18)12-13-5-2-1-3-6-13/h1-11H,12H2,(H,19,20)/b21-18-

SMILES Code

O=C(C1=CNC2=NC=CC=C21)/N=C3SC=CN\3CC4=CC=CC=C4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 334.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Xie H, Zhu Z, Tang J, Zhu W, Zhu M, Yi Wai AW, Li J, Wu Z, Tam PKH, Lui VCH, Tang W. Dysregulated Activation of Hippo-YAP1 Signaling Induces Oxidative Stress and Aberrant Development of Intrahepatic Biliary Cells in Biliary Atresia. Lab Invest. 2024 Nov 22;105(2):102199. doi: 10.1016/j.labinv.2024.102199. Epub ahead of print. PMID: 39579985. 2: Li Y, Ge L, Ren B, Zhang X, Yin Z, Liu H, Yang Y, Liu Y, Xu H. De- Differentiation of Corneal Epithelial Cells Into Functional Limbal Epithelial Stem Cells After the Ablation of Innate Stem Cells. Invest Ophthalmol Vis Sci. 2024 Nov 4;65(13):32. doi: 10.1167/iovs.65.13.32. PMID: 39546294; PMCID: PMC11578144. 3: Klaihmon P, Lorthongpanich C, Kheolamai P, Saisaard W, Issaragrisil S. Inhibition of LATS kinases reduces tumorigenicity and increases the sensitivity of human chronic myelogenous leukemia cells to imatinib. Sci Rep. 2024 Feb 18;14(1):3993. doi: 10.1038/s41598-024-54728-z. PMID: 38368446; PMCID: PMC10874434. 4: Hile GA, Coit P, Xu B, Victory AM, Gharaee-Kermani M, Estadt SN, Maz MP, Martens JWS, Wasikowski R, Dobry C, Tsoi LC, Iglesias-Bartolome R, Berthier CC, Billi AC, Gudjonsson JE, Sawalha AH, Kahlenberg JM. Regulation of Photosensitivity by the Hippo Pathway in Lupus Skin. Arthritis Rheumatol. 2023 Jul;75(7):1216-1228. doi: 10.1002/art.42460. Epub 2023 Apr 18. PMID: 36704840; PMCID: PMC10313771. 5: Wang Y, Liu X, Jing H, Ren H, Xu S, Guo M. Trimethyltin induces apoptosis and necroptosis of mouse liver by oxidative stress through YAP phosphorylation. Ecotoxicol Environ Saf. 2022 Dec 15;248:114327. doi: 10.1016/j.ecoenv.2022.114327. Epub 2022 Nov 23. PMID: 36434999. 6: Kastan NR, Oak S, Liang R, Baxt L, Myers RW, Ginn J, Liverton N, Huggins DJ, Pichardo J, Paul M, Carroll TS, Nagiel A, Gnedeva K, Hudspeth AJ. Development of an improved inhibitor of Lats kinases to promote regeneration of mammalian organs. Proc Natl Acad Sci U S A. 2022 Jul 12;119(28):e2206113119. doi: 10.1073/pnas.2206113119. Epub 2022 Jul 8. PMID: 35867764; PMCID: PMC9282237. 7: Piccolo FM, Kastan NR, Haremaki T, Tian Q, Laundos TL, De Santis R, Beaudoin AJ, Carroll TS, Luo JD, Gnedeva K, Etoc F, Hudspeth AJ, Brivanlou AH. Role of YAP in early ectodermal specification and a Huntington's Disease model of human neurulation. Elife. 2022 Apr 22;11:e73075. doi: 10.7554/eLife.73075. PMID: 35451959; PMCID: PMC9033270.