JNJ-7184 | RSV inhibitor

MedKoo Cat#: 127379 | Name: JNJ-7184

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JNJ-7184 is an RSV inhibitor.

Chemical Structure

JNJ-7184

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 127379

Name: JNJ-7184

CAS#: N/A

Chemical Formula: C30H27FN4O3

Exact Mass: 510.2067

Molecular Weight: 510.57

Elemental Analysis: C, 70.57; H, 5.33; F, 3.72; N, 10.97; O, 9.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

JNJ-7184; JNJ7184; JNJ 7184

IUPAC/Chemical Name

(1S,2S)-2-(4-(7-cyclopropyl-5-((R)-1-methyl-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)pyrazolo[1,5-a]pyrimidin-2-yl)-3-fluorophenyl)cyclopropane-1-carboxylic acid

InChi Key

MBPRXFPDWJSDRO-SOJKGPRNSA-N

InChi Code

InChI=1S/C30H27FN4O3/c1-16-20-5-3-2-4-17(20)10-11-34(16)29(36)26-14-27(18-6-7-18)35-28(32-26)15-25(33-35)21-9-8-19(12-24(21)31)22-13-23(22)30(37)38/h2-5,8-9,12,14-16,18,22-23H,6-7,10-11,13H2,1H3,(H,37,38)/t16-,22-,23?/m1/s1

SMILES Code

C[C@H]1N(C(C2=NC3=CC(C4=CC=C([C@H]5C[C@@H]5C(O)=O)C=C4F)=NN3C(C6CC6)=C2)=O)CCC7=C1C=CC=C7

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 510.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Bonneux B, Shareef A, Tcherniuk S, Anson B, de Bruyn S, Verheyen N, Thys K, Conceição-Neto N, Van Ginderen M, Kwanten L, Ysebaert N, Vranckx L, Peeters E, Lanckacker E, Gallup JM, Sitthicharoenchai P, Alnajjar S, Ackermann MR, Adhikary S, Bhaumik A, Patrick A, Fung A, Sutto-Ortiz P, Decroly E, Mason SW, Lançois D, Deval J, Jin Z, Eléouët JF, Fearns R, Koul A, Roymans D, Rigaux P, Herschke F. JNJ-7184, a respiratory syncytial virus inhibitor targeting the connector domain of the viral polymerase. Antiviral Res. 2024 Jul;227:105907. doi: 10.1016/j.antiviral.2024.105907. Epub 2024 May 19. PMID: 38772503.