(S,R,S)-AHPC-PEG4-NH2 is a VHL ligand with a linker, which is a useful precursor for synthesis of VHL ligand based PROTAC (proteolysis-targeting chimera) protein degrader. Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to tackle disease-causing proteins that have historically been highly challenging to target with conventional small molecules. PROTAC degraders are usually heterobifunctional small molecules consisting of two ligands joined by a linker: one ligand recruits and binds a protein of interest (POI) while the other recruits and binds an E3 ubiquitin ligase. Simultaneous binding of the POI and ligase by the PROTAC induces ubiquitylation of the POI and its subsequent degradation by the ubiquitin–proteasome system (UPS), after which the PROTAC is recycled to target another copy of the POI.
MedKoo Cat#: 466119
Name: (S,R,S)-AHPC-PEG4-NH2
CAS#: 2010159-57-4
Chemical Formula: C32H49N5O8S
Exact Mass: 663.3302
Molecular Weight: 663.83
Elemental Analysis: C, 57.90; H, 7.44; N, 10.55; O, 19.28; S, 4.83
The following data is based on the product molecular weight 663.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
