(S,R,S)-AHPC-PEG4-COOH is a VHL ligand with a linker, which is a useful precursor for synthesis of VHL ligand based PROTAC (proteolysis-targeting chimera) protein degrader. Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to tackle disease-causing proteins that have historically been highly challenging to target with conventional small molecules. PROTAC degraders are usually heterobifunctional small molecules consisting of two ligands joined by a linker: one ligand recruits and binds a protein of interest (POI) while the other recruits and binds an E3 ubiquitin ligase.
MedKoo Cat#: 577892
Name: (S,R,S)-AHPC-PEG4-COOH
CAS#: Unknown
Chemical Formula: C33H48N4O10S
Exact Mass: 692.3091
Molecular Weight: 692.82
Elemental Analysis: C, 57.21; H, 6.98; N, 8.09; O, 23.09; S, 4.63
The following data is based on the product molecular weight 692.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
