MedKoo Cat#: 471139 | Name: BAY-179
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

BAY-179 is a potent, selective, and species cross-reactive OXPHOS complex I inhibitor. BAY-179 displayed moderate to good in vitro metabolic stability, BAY-179 is an excellent in vivo suitable tool with which to probe the biological relevance of complex I inhibition in cancer indications.

Chemical Structure

BAY-179
BAY-179
CAS#2764880-87-5

Theoretical Analysis

MedKoo Cat#: 471139

Name: BAY-179

CAS#: 2764880-87-5

Chemical Formula: C23H21N5OS

Exact Mass: 415.1470

Molecular Weight: 415.52

Elemental Analysis: C, 66.48; H, 5.09; N, 16.85; O, 3.85; S, 7.72

Price and Availability

Size Price Availability Quantity
25mg USD 250.00 2 Weeks
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
200mg USD 1,250.00 2 Weeks
500mg USD 2,650.00 2 Weeks
1g USD 4,250.00 2 Weeks
2g USD 6,250.00 2 Weeks
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Related CAS #
No Data
Synonym
BAY-179; BAY 179; BAY179
IUPAC/Chemical Name
2-(1-((1H-Imidazo[4,5-b]pyridin-2-yl)methyl)piperidin-4-yl)-4-(benzofuran-2-yl)thiazole
InChi Key
JOCPQSJABURDDD-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H21N5OS/c1-2-6-19-16(4-1)12-20(29-19)18-14-30-23(26-18)15-7-10-28(11-8-15)13-21-25-17-5-3-9-24-22(17)27-21/h1-6,9,12,14-15H,7-8,10-11,13H2,(H,24,25,27)
SMILES Code
C1(C2CCN(CC3=NC4=NC=CC=C4N3)CC2)=NC(C5=CC6=CC=CC=C6O5)=CS1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 415.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Mowat J, Ehrmann AHM, Christian S, Sperl C, Menz S, Günther J, Hillig RC, Bauser M, Schwede W. Identification of the Highly Active, Species Cross-Reactive Complex I Inhibitor BAY-179. ACS Med Chem Lett. 2022 Feb 18;13(3):348-357. doi: 10.1021/acsmedchemlett.1c00666. PMID: 35300083; PMCID: PMC8919281.