Synonym
RY785; RY-785; RY 785;
IUPAC/Chemical Name
3-methoxy-α-methyl-N-[2-(4-thiazolyl)-1H-benzimidazol-6-yl]-benzenepropanamide
InChi Key
BRHVBJUDTWQELF-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H20N4O2S/c1-13(8-14-4-3-5-16(9-14)27-2)21(26)23-15-6-7-17-18(10-15)25-20(24-17)19-11-28-12-22-19/h3-7,9-13H,8H2,1-2H3,(H,23,26)(H,24,25)
SMILES Code
O=C(NC1=CC=C2N=C(C3=CSC=N3)NC2=C1)C(C)CC4=CC=CC(OC)=C4
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
392.48
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Marquis MJ, Sack JT. Mechanism of use-dependent Kv2 channel inhibition by RY785. J Gen Physiol. 2022 Jun 6;154(6):e202112981. doi: 10.1085/jgp.202112981. Epub 2022 Apr 18. PMID: 35435946; PMCID: PMC9195051.
2: Short B. A Kv2 inhibitor traps itself in place. J Gen Physiol. 2022 Jun 6;154(6):e202213181. doi: 10.1085/jgp.202213181. Epub 2022 May 6. PMID: 35522189; PMCID: PMC9086499.
3: Zhang S, Stix R, Orabi EA, Bernhardt N, Faraldo-Gomez JD. Distinct mechanisms of inhibition of Kv2 potassium channels by tetraethylammonium and RY785. bioRxiv [Preprint]. 2024 Jul 25:2024.07.25.605170. doi: 10.1101/2024.07.25.605170. PMID: 39372771; PMCID: PMC11451595.
4: Stewart RG, Marquis MJ, Jo S, Aberra A, Cook V, Whiddon Z, Ferns M, Sack JT. A Kv2 inhibitor combination reveals native neuronal conductances consistent with Kv2/KvS heteromers. bioRxiv [Preprint]. 2024 May 14:2024.01.31.578214. doi: 10.1101/2024.01.31.578214. PMID: 38352561; PMCID: PMC10862871.
5: Wang X, Zhang X, Zhou J, Wang W, Wang X, Xu B. An in silico investigation of Kv2.1 potassium channel: Model building and inhibitors binding sites analysis. Mol Inform. 2023 Dec;42(12):e202300072. doi: 10.1002/minf.202300072. Epub 2023 Nov 7. PMID: 37793122.
6: Herrington J, Solly K, Ratliff KS, Li N, Zhou YP, Howard A, Kiss L, Garcia ML, McManus OB, Deng Q, Desai R, Xiong Y, Kaczorowski GJ. Identification of novel and selective Kv2 channel inhibitors. Mol Pharmacol. 2011 Dec;80(6):959-64. doi: 10.1124/mol.111.074831. Epub 2011 Sep 26. PMID: 21948463.
