U0126-EtOH | CAS#1173097-76-1 | MEK1/2 Inhibitor

MedKoo Cat#: 533010 | Name: U0126-EtOH

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. This inhibition of MEK1/2 is noncompetitive with ERK and ATP.

Chemical Structure

U0126-EtOH

CAS#1173097-76-1 (EtOH)

Theoretical Analysis

MedKoo Cat#: 533010

Name: U0126-EtOH

CAS#: 1173097-76-1 (EtOH)

Chemical Formula: C20H22N6OS2

Exact Mass: 426.1297

Molecular Weight: 426.56

Elemental Analysis: C, 56.32; H, 5.20; N, 19.70; O, 3.75; S, 15.03

Price and Availability

Size	Price	Availability
50mg	USD 550.00	2 Weeks
100mg	USD 950.00	2 Weeks
200mg	USD 1,450.00	2 Weeks
500mg	USD 2,650.00	2 Weeks
1g	USD 3,650.00	2 Weeks
2g	USD 6,250.00	2 Weeks

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Related CAS #

109511-58-2 (free) 218601-62-8 (ZZ-isomer) 218601-64-0 (EE-isomer) 1173097-76-1 (EtOH)

Synonym

U0126-EtOH; U0126EtOH; U0126 EtOH, U0126, U-0126, U 0126

IUPAC/Chemical Name

(2Z,3Z)-2,3-bis(amino((2-aminophenyl)thio)methylene)succinonitrile compound with ethanol (1:1)

InChi Key

CFQULUVMLGZVAF-OYJDLGDISA-N

InChi Code

InChI=1S/C18H16N6S2.C2H6O/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22;1-2-3/h1-8H,21-24H2;3H,2H2,1H3/b17-11+,18-12+;

SMILES Code

CCO.C1=CC=C(C(=C1)N)SC(=C(C#N)C(=C(N)SC2=CC=CC=C2N)C#N)N

Appearance

White to off-white solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 426.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Shao S, Xia H, Hu M, Chen C, Fu J, Shi G, Guo Q, Zhou Y, Wang W, Shi J, Zhang T. Isotalatizidine, a C19-diterpenoid alkaloid, attenuates chronic neuropathic pain through stimulating ERK/CREB signaling pathway-mediated microglial dynorphin A expression. J Neuroinflammation. 2020 Jan 10;17(1):13. doi: 10.1186/s12974-019-1696-9. PMID: 31924228; PMCID: PMC6953278. 2: Xu P, Bao R, Zhang Y, Lu E, Feng F, Zhang L, Li J, Wang J, Tan X, Tang M, Hu C, Li G, Zhang C. Prolyl oligopeptidase regulates progesterone secretion via the ERK signaling pathway in murine luteal cells. Mol Reprod Dev. 2019 Jun;86(6):714-726. doi: 10.1002/mrd.23149. Epub 2019 Apr 16. PMID: 30990944. 3: Liu F, Feng XX, Zhu SL, Huang HY, Chen YD, Pan YF, June RR, Zheng SG, Huang JL. Sonic Hedgehog Signaling Pathway Mediates Proliferation and Migration of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via MAPK/ERK Signaling Pathway. Front Immunol. 2018 Dec 5;9:2847. doi: 10.3389/fimmu.2018.02847. PMID: 30568656; PMCID: PMC6290332. 4: Zhang C, Li J, Aji T, Li L, Bi X, Yang N, Li Z, Wang H, Mao R, Lü G, Shao Y, Vuitton DA, Wen H, Lin R. Identification of Functional MKK3/6 and MEK1/2 Homologs from Echinococcus granulosus and Investigation of Protoscolecidal Activity of Mitogen-Activated Protein Kinase Signaling Pathway Inhibitors In Vitro and In Vivo. Antimicrob Agents Chemother. 2018 Dec 21;63(1):e01043-18. doi: 10.1128/AAC.01043-18. PMID: 30348669; PMCID: PMC6325220. 5: Wang TT, Zhai L, Zhang HY, Zhao L, Guo YL. [Effect of Picroside II on ERK1/2 Signal Pathway in Cerebral lschemic Injury Rats]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2016 Apr;36(4):437-44. Chinese. PMID: 27323616. 6: Lv J, Sun X, Ma J, Ma X, Zhang Y, Li F, Li Y, Zhao Z. Netrin-1 induces the migration of Schwann cells via p38 MAPK and PI3K-Akt signaling pathway mediated by the UNC5B receptor. Biochem Biophys Res Commun. 2015 Aug 14;464(1):263-8. doi: 10.1016/j.bbrc.2015.06.140. Epub 2015 Jun 23. PMID: 26116534.