GSK3685032 is a first-in-class potent, non-nucleoside, reversible, DNMT1-selective inhibitor (IC50: 0.17 µM), exerting robust DNA hypomethylation and gene activation, potently inhibiting growth of cancer cell lines, displaying improved tolerability and greater DNA hypomethylation than decitabine (DAC), translating into superior antitumour activity in models of AML.
MedKoo Cat#: 466040
Name: GSK3685032
CAS#: 2170137-61-6 (free base)
Chemical Formula: C22H24N6OS
Exact Mass: 420.1732
Molecular Weight: 420.54
Elemental Analysis: C, 62.83; H, 5.75; N, 19.98; O, 3.80; S, 7.62
The following data is based on the product molecular weight 420.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
