MT-7716 is a novel selective nonpeptidergic NOP receptor agonist, effectively blocks ethanol-induced increase in GABAergic transmission in the rat central amygdala. MT-7716 dose-dependently (100-1000 nM) diminished evoked GABAA receptor-mediated inhibitory postsynaptic potentials (IPSPs) and increased paired-pulse facilitation (PPF) ratio of these evoked IPSPs, suggesting a presynaptic site of action of the MT-7716 by decreasing GABA release at CeA synapses. MT-7716 prevented the ethanol-induced augmentation of evoked IPSPs. MT-7716 significantly attenuated somatic alcohol withdrawal symptoms. MT-7716 is a promising candidate for alcoholism treatment remaining effective with chronic administration.
MedKoo Cat#: 577798
Name: MT-7716 HCl hydrate
CAS#: 1215859-92-9 (HCl hydrate)
Chemical Formula: C27H31ClN4O3
Exact Mass: 494.2085
Molecular Weight: 495.02
Elemental Analysis: C, 65.51; H, 6.31; Cl, 7.16; N, 11.32; O, 9.70
The following data is based on the product molecular weight 495.02 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
