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MedKoo Cat#: 577785 | Name: MRS-2339

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MRS-2339 is a P2X receptor activator.

Chemical Structure

MRS-2339
MRS-2339
CAS#436847-13-1

Theoretical Analysis

MedKoo Cat#: 577785

Name: MRS-2339

CAS#: 436847-13-1

Chemical Formula: C12H15ClN5O6P

Exact Mass: 391.0448

Molecular Weight: 391.70

Elemental Analysis: C, 36.80; H, 3.86; Cl, 9.05; N, 17.88; O, 24.51; P, 7.91

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
MRS-2339; MRS 2339; MRS2339
IUPAC/Chemical Name
(1R,2R,3S,4R,5S)-4-(6-Amino-2-chloro-9H-purin-9-yl)-1-((phosphonooxy)methyl)bicyclo(3.1.0)hexane-2,3-diol
InChi Key
FTSUGKZNIRUKKK-OBPILZPTSA-N
InChi Code
1S/C12H15ClN5O6P/c13-11-16-9(14)5-10(17-11)18(3-15-5)6-4-1-12(4,8(20)7(6)19)2-24-25(21,22)23/h3-4,6-8,19-20H,1-2H2,(H2,14,16,17)(H2,21,22,23)/t4-,6-,7+,8+,12+/m1/s1
SMILES Code
Nc1nc(Cl)nc2c1ncn2[C@H]3[C@H](O)[C@H](O)[C@]4(COP(=O)(O)O)C[C@H]34
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 391.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Kumar TS, Zhou SY, Joshi BV, Balasubramanian R, Yang T, Liang BT, Jacobson KA. Structure-activity relationship of (N)-Methanocarba phosphonate analogues of 5'-AMP as cardioprotective agents acting through a cardiac P2X receptor. J Med Chem. 2010 Mar 25;53(6):2562-76. doi: 10.1021/jm9018542. PMID: 20192270; PMCID: PMC2880888. 2. Zhou SY, Mamdani M, Qanud K, Shen JB, Pappano AJ, Kumar TS, Jacobson KA, Hintze T, Recchia FA, Liang BT. Treatment of heart failure by a methanocarba derivative of adenosine monophosphate: implication for a role of cardiac purinergic P2X receptors. J Pharmacol Exp Ther. 2010 Jun;333(3):920-8. doi: 10.1124/jpet.109.164376. Epub 2010 Mar 3. PMID: 20200116; PMCID: PMC2879931. 3. Shen JB, Cronin C, Sonin D, Joshi BV, Gongora Nieto M, Harrison D, Jacobson KA, Liang BT. P2X purinergic receptor-mediated ionic current in cardiac myocytes of calsequestrin model of cardiomyopathy: implications for the treatment of heart failure. Am J Physiol Heart Circ Physiol. 2007 Feb;292(2):H1077-84. doi: 10.1152/ajpheart.00515.2006. Epub 2006 Oct 13. PMID: 17040972; PMCID: PMC6252253.